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Abstract: TH-PO792

Bioelectrical Impedance Analysis Derived-Phase Angle as an Earlier Predictor of Frailty in Hemodialysis Patients

Session Information

Category: Geriatric Nephrology

  • 1200 Geriatric Nephrology

Authors

  • Gómez Ruiz, Ismael Antonio, Medica Santa Carmen, Ciudad de México, CIUDAD DE MEXICO, Mexico
  • Hernández Apolinar, Oscar, Medica Santa Carmen, Ciudad de México, CIUDAD DE MEXICO, Mexico
  • Hernandez Espinoza, Samantha, Medica Santa Carmen, Ciudad de México, CIUDAD DE MEXICO, Mexico
  • Martin-Alemañy, Geovana, Medica Santa Carmen, Ciudad de México, CIUDAD DE MEXICO, Mexico
  • Ardavin Ituarte, Juan M., Medica Santa Carmen, Ciudad de México, CIUDAD DE MEXICO, Mexico
Background

Frailty is highly prevalent in the hemodialysis (HD) patient population (28-60%) and is associated with higher morbidity and mortality. Early frailty identification will allow earlier treatment interventions. The aim of the present study was to study phase angle (PA) measured by bioelectrical impedance analysis (BIA) as a predictor of frailty risk. Secondary aims were: a) evaluate the association between frailty and different factors, b) determine the prevalence of frailty among adult patients on hemodialysis.

Methods

prospective cohort study performed between July 2021 and April 2022 in two Mexican HD centers. The Clinical Frailty Scale (CFS) was used to diagnose frailty. Using ROC curves, we determined the best cut-off for PA to predict frailty (Figure A). Pearson's correlation coefficient between PA and CFS score were calculated and univariate logistic regression analysis was performed (Figure B)

Results

78 patients were enrolled in this study. Participants were an average of 63.7 ± 14.3 years old with more male gender (62.8%) than female. 60.2% of participants were categorized as frailty. As expected, patients with frailty were older, had lower PA value and higher CFS score. Frailty was more prevalent in males and smokers. The AUC of PA to predict frailty was 0.87 (p<0.0001). Moderate-to-strong negative correlation was found between PA and CFS score (r=-0.58, p<0.0001). A univariate logistic regression analysis revealed that the factors independently associated with frailty were the following: male (odds ratio [OR] = 3.01, 95% confidence interval [CI] 1.09-8.35), age (OR = 1.04, 95% CI 1.00-1.08) and phase angle (OR = 0.51, 95% CI 0.34-0.75).

Conclusion

A simple PA determination (<5.3) by BIA can predict risk of frailty (sensitive 85% and specificity 84%) in HD patients. The use of PA as a screening tool at no extra cost would allow early identification of frailty and referral for geriatric evaluation.