Kidney Week

Abstract: TH-PO868

Plasma KIM-1, MCP-1, suPAR, TNFR1, and TNFR2 Are Associated With Incident CKD in Individuals Without Diabetes

Session Information

• CKD: Epidemiology, Risk Factors, Prevention - I
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention

Author

• Le, Dustin, Johns Hopkins Medicine, Baltimore, Maryland, United States

Dustin Le,

Group or Team Name

• Chronic Kidney Disease Biomarkers Consortium

Background

Numerous kidney biomarkers related to tubular injury, inflammation, and repair have been associated with kidney disease progression in patients with diabetes and underlying chronic kidney disease (CKD). Whether these markers are associated with incident CKD in a general population without diabetes is not well established.

Methods

In a nested case-cohort study within the Atherosclerosis Risk in Communities (ARIC) study, we evaluated the association of plasma biomarkers related to tubular injury (kidney injury molecule-1 [KIM-1]), inflammation (monocyte chemoattractant protein-1[MCP-1], soluble urokinase plasminogen activator receptor [suPAR], tumor necrosis factor receptor 1 [TNFR-1], tumor necrosis factor receptor 2 [TNFR-2]), and repair (human cartilage glycoprotein-39 [YKL-40]) and risk of incident CKD among individuals with baseline eGFR ≥ 60 mL/min and no diabetes. Biomarkers were measured at visit 4 (1996-1998). Incident CKD was defined as eGFR <60 mL/min per 1.73 m² and ≥ 40% eGFR decline at visit 5 (2011- 2013) or end stage kidney disease through linkage with the USRDS registry.

Results

There were 523 incident CKD cases (38 being ESRD) and 425 non-cases. Mean age was 62 years, 59% were women, and 20% were black. Mean baseline eGFR was 88 (5^th- 95^th percentile: 66 - 108). In multivariable analyses, there was a higher risk of incident CKD per two-fold higher concentration of KIM-1 (HR 1.35, 95% CI: 1.22 - 1.50), MCP-1 (HR 1.36, 95% CI: 1.12 -1.65), suPAR (HR 1.69, 95% CI: 1.37 - 2.08), TNFR-1 (HR 1.54, 95% CI: 1.32 - 1.80), and TNFR-2 (HR 1.69, 95% CI: 1.35 - 2.11). See Figure for results by biomarker quartile. YKL-40 was not significant.

Conclusion

Higher plasma levels of KIM-1, MCP-1, suPAR, TNFR-1, and TNFR-2 were associated with increased risk of incident CKD in a general population study.

Funding

• NIDDK Support