Abstract: FR-OR21
Air Pollution, Genetic Factors, and the Risk of Incident CKD: A Prospective Study of Polygenic Risk Score Analysis in the UK Biobank
Session Information
- CKD: Clinical Outcomes, Trials, Mechanistic Insights
November 04, 2022 | Location: W307, Orange County Convention Center‚ West Building
Abstract Time: 04:30 PM - 04:39 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention
Authors
- Weon, Boram, Seoul National University Boramae Medical Center, Seoul, Korea (the Republic of)
- Lee, Jeonghwan, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
- Lee, Jung Pyo, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
- Lim, Chun Soo, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
Background
Both genetic and environmental factors contribute to chronic kidney disease (CKD), but the degree to which air pollution modifies the impact of genetic susceptibility on CKD remains unknown. We aimed to investigate the effects and their interaction of air pollution and genetic factors on incident CKD.
Methods
We analyzed data from 350,994 participants (53% women) without previous CKD at baseline in the UK Biobank. The concentrations of particulate matter (PM) (PM <2.5 mm in aerodynamic diameter [PM2.5], coarse PM between 2.5 mm and 10 mm in aerodynamic diameter [PMcoarse], and PM <10 mm in aerodynamic diameter [PM10]), nitrogen dioxide (NO2), and nitrogen oxides (NOx) were estimated by using land-use regression models, and the association between air pollutants and incident CKD was investigated by using a Cox proportional hazard model. Furthermore, we constructed a polygenic risk score and evaluated whether air pollutants modified the effect of genetic susceptibility on the development of CKD.
Results
The results showed significant associations between the risk of CKD and PM2.5 (hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.06–1.37) and NOx (HR,1.19; 95% CI, 1.05–1.35). There were additive interactions between air pollutants and the genetic risk in PM10 and PMcoarse. Compared with participants with high genetic risk score groups, those with high air pollution exposure and low genetic risk showed significantly increased hazards for incident CKD (PM2.5: HR, 1.21; 95% CI, 1.06–1.37; NOx: HR, 1.19; 95% CI, 1.05–1.35).
Conclusion
Long-term exposure to air pollution may increase the risk of CKD, especially in those with low genetic risk.