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Abstract: FR-PO098

Clinical Characteristics of AKI in Patients With Glyphosate Surfactant Herbicide Poisoning

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Sun, In O, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)
  • Cho, A young, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)
Background

In this study, we investigated the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GSH) poisoning.

Methods

This study performed between 2008 and 2021 included 184 patients categorized into AKI and non-AKI groups. The incidence, clinical characteristics, and severity of AKI were compared between the AKI (n=82) and non-AKI (n=102) groups, based on the Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease classification.

Results

The incidence of AKI was 44.5%, of which 25.0%, 6.5%, and 13.0% patients were classified into the Risk, Injury, and Failure categories, respectively. Patients in the AKI group were older (63.3±16.2 years vs. 57.4±17.5 years, P=0.020) and had ≥1 comorbidities (52.4% vs. 32.7%, P=0.005) than those in the non-AKI group. The length of hospitalization was longer (10.7±12.1 days vs. 6.5±8.1 days, P=0.004), and hypotensive episodes occurred more frequently in the AKI group (45.1% vs. 8.8%, P<0.001). Electrocardiographic (ECG) abnormalities on admission were more frequently observed in the AKI than in the non-AKI group (80.5% vs. 47.1%, P<0.001). Patients in the AKI group had poorer renal function (62.2±22.9 mL/min/1.73 m2 vs. 88.9±26.1 mL/min/1.73 m2, P<0.001) on admission. The mortality rate was higher in the AKI than in the non-AKI group (18.3% vs. 1.0%, P<0.001). Multiple logistic regression analysis showed that hypotension and ECG abnormalities upon admission were significant predictors of AKI in patients with GSH poisoning.

Conclusion

Blood pressure and ECG findings on admission may be useful predictors of AKI in patients with GSH intoxication.