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Abstract: TH-PO396

Bone Mineral Density in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients After Kidney Transplantation

Session Information

Category: Genetic Diseases of the Kidneys

  • 1101 Genetic Diseases of the Kidneys: Cystic


  • Zubidat, Dalia, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Hanna, Christian, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Chedid, Maroun, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Sfeir, Jad G., Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Chebib, Fouad T., Mayo Clinic in Florida, Jacksonville, Florida, United States

ADPKD is caused by pathogenic variants in PKD1 or PKD2, encoding polycystin-1 and -2 proteins. Polycystins are expressed in animal models’ osteoblasts and chondrocytes, and their loss-of-function is associated with low bone density (BMD) and volume. It is unclear whether these variants have an impact on bone strength in patients with ADPKD; thus, we examined bone phenotype in ADPKD after kidney transplantation to minimize the confounding effect of chronic kidney disease-related renal osteodystrophy.


This single-center retrospective observational study retrieved data from adult patients who received a kidney transplant between 01/2005 and 03/2020. Patients with available at and post-transplant dual-energy X-ray absorptiometry (DXA) of the hip and/or lumbar spine (LS) were included. ADPKD patients (n=373) were matched 1:1 by age (±2 years) at kidney transplantation and sex with non-ADPKD patients (n=373).


DXA was obtained at a mean of 6 years following transplant. As compared to non-ADPKD, patients with ADPKD had slightly higher BMD T-scores at left femoral neck (FN) (-1.3 vs. -1.6, p<0.01), right FN (-1.3 vs. -1.4, p<0.01), left total hip (TH) (-0.5 vs. -1.1, p<0.01) and right TH (-0.7 vs -1.1, p<0.01) but worse T-score at LS (-0.8 vs -0.4, p=0.01). ADPKD patients continued to have higher BMD T-scores in FN and TH, after adjusting for receiving preemptive kidney transplants.


Our findings suggest that BMD by DXA is generally preserved in patients with ADPKD following kidney transplantation, despite slightly lower T-scores at the LS.

Table 1 - Baseline demographic, and clinical, characteristics in ADPKD and non-ADPKD patients post kidney transplantation.