Abstract: TH-PO820
Objective Physical Activity Is Associated With Glycemic Variability in Patients With CKD
Session Information
- Health Maintenance, Nutrition, Metabolism
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance‚ Nutrition‚ and Metabolism
- 1400 Health Maintenance‚ Nutrition‚ and Metabolism
Authors
- Mowrey, John, University of California Davis, Sacramento, California, United States
- Mehmood, Zaneb, University of California Davis, Sacramento, California, United States
- Badhesha, Harshanna, University of California Davis, Sacramento, California, United States
- Batra, Radhika, University of California Davis, Sacramento, California, United States
- Hamdan, Hiba, University of California Davis, Sacramento, California, United States
- Kim, Tae Youn, University of California Davis, Sacramento, California, United States
- Roshanravan, Baback, University of California Davis, Sacramento, California, United States
Background
Sedentary behavior is highly prevalent in patients with Chronic Kidney Disease (CKD) and strongly associated with adverse metabolic and clinical outcomes across populations. However, associations of objective and self-reported physical activity with clinically relevant measures of glycemic variability in patients with CKD remain unknown.
Methods
We performed a cross-sectional study in 25 patients with moderate-severe CKD simultaneously wearing an ActivPAL 4 accelerometer and Abbott Freestyle Libre Pro continuous glucose monitor (CGM) for 2 weeks. Self-reported physical activity was evaluated using the Human Activities Profile (HAP), divided into maximal and adjusted activity scores. Linear regression was used to test associations of measures of physical activity and CGM.
Results
Mean eGFR of our sample was 35.72 ±11.54ml/min with 48% female, and 56% with diabetes. Average sitting time in the cohort was 527 ±168min/day. We observed that greater sitting time correlates with worsening glucose control including higher average glucose (P=0.04), decreased time in target (p=0.04), and increased time above target (p=0.007). Each 1-SD increase in sitting time was associated with a 0.77SD lower (95% CI 0.65SD, 2.11SD lower; p=0.001) time in target range (70-140mg/dL) independent of diabetes status, sex, and BMI. We did not see any meaningful or significant association of impact on self-reported physical activity on CGM readings.
Conclusion
Objective measurement of sitting time is strongly associated with worse glycemic control in patients with CKD. Future intervention studies are needed to determine if physical activity interventions improve glycemic control in CKD patients with, and without diabetes.