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Abstract: TH-PO576

Cumulative Smoking Dose Is a Risk Factor for Renal Arteriolar Hyalinization and Glomerular Sclerosis in Individuals Without CKD: A Cross-Sectional Study

Session Information

  • Pathology and Lab Medicine
    November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pathology and Lab Medicine

  • 1700 Pathology and Lab Medicine


  • Ataka, Eri, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Matsukuma, Yuta, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Ueki, Kenji, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Tsuchimoto, Akihiro, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Okabe, Yasuhiro, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Masutani, Kosuke, Fukuoka Daigaku, Fukuoka, Fukuoka, Japan
  • Nakano, Toshiaki, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Kitazono, Takanari, Kyushu Daigaku, Fukuoka, Fukuoka, Japan

Cigarette smoking is an established risk factor for the development of chronic kidney disease (CKD). However, the renal pathological lesions related to smoking have not been clearly elucidated in healthy participants. In this study, we investigated the relationship between cumulative smoking dose and renal microstructural features in participants without CKD.


We evaluated the time-zero biopsy specimen of 547 living kidney donors. Renal arteriolar hyalinization, intimal thickening of small-medium arteries, glomerular sclerosis and interstitial fibrosis and tubular atrophy (IF/TA) were investigated.


In total, 199 patients (36.4%) had smoking history, 92 (16.8%) of them were with <20 pack-years and 107 (19.6%) were with ≥20 pack-years. Increase in cumulative smoking dose was significantly associated with the prevalence of arteriolar hyalinization in multivariable logistic analysis. Odds ratio (OR) (95% confidence interval [CI]) for arteriolar hyalinization per 20 pack-years increase was 1.52 (1.18-1.95) and those of the group with <20 pack-years and with ≥20 pack-years vs. non-smokers were 1.73 (1.01-2.94) and 2.38 (1.43-3.97), respectively. Increase in smoking dose was also related to the prevalence of >10% global glomerular sclerosis. OR (95% CI) for >10% global glomerular sclerosis per 20 pack-years increase was 1.25 (0.98-1.58) and those of the group with <20 pack-years and with ≥20 pack-years vs non-smokers were 1.39 (0.77-2.52) and 1.93 (1.11-3.35), respectively. Intimal thickening of small- to medium-sized arteries and IF/TA were not associated with smoking dose.


Cumulative smoking dose was an independent risk factor for renal arteriolar hyalinization and abnormal glomerulosclerosis in individuals without chronic kidney disease.