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Abstract: TH-PO046

Serum Potassium Trajectory During AKI and Mortality

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical‚ Outcomes‚ and Trials

Authors

  • Chavez, Jonathan, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Navarro Blackaller, Guillermo, Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico
  • Maggiani, Pablo, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Diaz Villavicencio, Bladimir, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Oliva, Ana Elisa, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • de la Vega Méndez, Frida Margarita, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Garcia-Garcia, Guillermo, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Calderon Garcia, Clementina Elizabeth, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Prieto Magallanes, Manuel Luis, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Martínez Gallardo González, Alejandro, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Romero, Alexia, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Background

The association between potassium (sK) trajectory and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been explored

Methods

In this prospective cohort study, AKI patients were divided in 8 groups based on sK (mEq/L) trajectories, (1) normoK, sK between 3.5-5.5; (2) corrected hyperK, sK > 5.5 to normoK; (3) corrected hypoK, sK < 3.5 to normoK; (4) fluctuating potassium, sK increased / decreased in and out of normoK; (5) uncorrected hypoK, sK < 3.5; (6) normoK to hypoK, sK normal and decreased to hypoK; (7) normoK to hyperK, (8) uncorrected hyperK, sK > 5.5. We assessed the association of sK trajectories with mortality and the need for KRT

Results

In 311 AKI patients. AKI 3 was present in 63.9%. KRT started in 36%, and 21.2% died. After adjusting for confounders, 10-day hospital mortality was higher in group 7 and 8 (OR, 1.37 and 1.63 p = <0.05, respectevely), and KRT initiation was higher in group 8 (OR 1.40 p = < 0.05) compared with group 1. Mortality in different subgroups of patients did not change the primary results

Conclusion

In our prospective cohort, most patients with AKI had dyskalemia. NormoK to hyperK and Uncorrected hyperK were associated with death, while only uncorrected hyperK was correlated with the need for KRT

The association between sK+ trajectories and 10-days mortality

OR of unadjusted 10-days mortality in different subgroups of patients with
uncorrected hyperK