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Abstract: TH-PO047

Serum Sodium Trajectory During AKI and Mortality Risk

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical‚ Outcomes‚ and Trials

Authors

  • Chavez, Jonathan, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Navarro Blackaller, Guillermo, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Carmona, Edgar Joel, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Arizaga Napoles, Manuel, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Hernandez Morales, Karla, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Garcia-Garcia, Guillermo, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Martínez Gallardo González, Alejandro, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Plascencia Cruz, Marcela, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
  • Ramos Avellaneda, Fidel, Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico
Background

The association between serum sodium (sNa) level and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury has not been explored

Methods

In this prospective cohort, we enrolled AKI patients and divided them into 5 groups based on the sNa level trajectories up to 10 days, 1) stable Na (135-145), 2) fluctuating Na levels (increased/decreased in and out of normonatremia), 3) uncorrected hyponatremia, 4) corrected hyponatremia, and 5) uncorrected hypernatremia. We assessed the association of sNa trajectories with mortality and the need for KRT

Results

A total of 288 patients were included. AKI3 was present in 50.4%. KRT started in 25% patients, and 15.6% died. After adjusting for confounders, 10-day hospital mortality was higher in group 5 (HR 3.12, p = 0.03), and KRT initiation was higher in group 3 (HR, 2.44;p = 0.03) compared with group 1

Conclusion

In our cohort, most patients with AKI had alterations in sNa. Uncorrected hypernatremia was associated with death, and uncorrected hyponatremia was correlated with the need for KRT

HRs unadjusted for 10-day mortality in different patient subgroups with
uncorrected hypernatremia and KRT initiaton HRs unadjusted need for KRT
initiation in different subgroups of patients with uncorrected hyponatremia

The association between sNa trajectories and 10-day mortality