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Abstract: TH-PO951

Characteristics of Vaccinated Kidney Transplant Recipients Requiring Hospitalization for COVID-19 Infection

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Rizvi, Ali Waris, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Turk, Michael, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Alhuneafat, Laith, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Gupta, Naman, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Shah, Aaisha, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Rana, Tabeer, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Gutta, Ramya, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Barnett, Katherine, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Mealy, Shane, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Sharma, Alisha, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Osman, Omar, Allegheny Health Network, Pittsburgh, Pennsylvania, United States
  • Sureshkumar, Kalathil K., Allegheny Health Network, Pittsburgh, Pennsylvania, United States
Background

Studies have shown suboptimal immunological response to COVID-19 vaccination in kidney transplant recipients (KTRs).
We aimed to describe specific characteristics of vaccinated KTRs who required hospitalization for COVID-19 infection.

Methods

In this descriptive study utilizing chart review, we identified KTRs who were hospitalized for COVID-19 infection between March 2020 and January 2022 within our integrated health network. Demographic characteristics were identified for KTRs who received ≥2 COVID-19 vaccine doses prior to hospitalization.

Results

Among 114 KTRs admitted to the hospital with COVID-19 infection, 44 (39%) had received 2 or more vaccine doses prior to hospitalization including 35 patients who received 2 vaccines and 9 who received >2 vaccines. Vaccinated patients requiring hospitalization were generally older with male predominance. Prevalent comorbidities included overweight/obesity, hypertension, and diabetes. Among these patients, 18% required dialysis and 90-day mortality was 20% (Table).

Conclusion

Despite receiving at least 2 doses of preventative vaccination, many KTRs developed COVID-19 infection requiring hospitalization. Our findings are consistent with studies showing reduced antibody and cell mediated response to vaccination in KTRs. Every effort should be made to educate and encourage this vulnerable population about measures to prevent infection, especially vaccination with subsequent booster doses.

Baseline Characteristics Total (n=44)
Age (years)61.6 ± 12.2
Body mass index29.1 ± 5.2
Sex: Female19 (43%)
Race: White, Black, Other29 (66%), 12 (27%), 3 (7%)
Hypertension, Diabetes41 (93%), 20 (46%)
CAD, CHF15 (34%), 12 (27%)
COPD6 (14%)
Immunosuppression: Tacrolimus, MMF, Steroids41 (93%), 36 (82%), 25 (57%)
Donor type: Deceased33 (75%)
Outcomes Total (n=44)
90-day mortality9 (20%)
Need for new dialysis8 (18%)
Length of Stay (days)8.5 ± 9.7

CAD=coronary artery disease; CHF=congestive heart failure; COPD=chronic obstructive pulmonary disease