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Abstract: SA-PO703

Minimal Change Disease Management and Outcomes: Observation Over 10 Years From a Single Adult Nephrology Centre

Session Information

Category: Glomerular Diseases

  • 1303 Glomerular Diseases: Clinical‚ Outcomes‚ and Trials

Authors

  • Oklopcic, Anja, Sheffield Kidney Institute, Sheffield, United Kingdom
  • Bowers, Corrie, Sheffield Kidney Institute, Sheffield, United Kingdom
  • Balasubramanian, Nithin, The University of Sheffield Medical School, Sheffield, Sheffield, United Kingdom
  • Khwaja, Arif, Sheffield Kidney Institute, Sheffield, United Kingdom
  • Salam, Syazrah, Sheffield Kidney Institute, Sheffield, United Kingdom
Background

Minimal change disease (MCD) is one of the causes of nephrotic syndrome. Disease response to corticosteroid varies and time to disease remission and relapse is unknown. We assessed: the remission and relapse rates,time from remission to first relapse, the proportion of patients on adjunct treatment, the proportion of patients with acute kidney injury( AKI) at initial presentation, clinical outcomes.

Methods

Single centre service evaluation. Adult patients with diagnosis of MCD. Between 1st January 2010 and 31st December 2019. Follow up data were collected until 31st December 2020.Patients from paediatric nephrology services were excluded

Results

41 patients (26 men, 15 women). All but one had histological diagnosis. Mean age 49 ± 17 years. 11 patients had AKI at presentation. 37/41 patients achieved remission; 26 had complete and 11 had partial remission. 24/37 patients relapsed but all subsequently achieved remission (21 complete and 3 partial remission). The median time from initial remission to first relapse was 168 days (IQR 71 – 327 days). 14/24 patients had a relapse within 6 months from initial remission. All patients received corticosteroid. Additional immunosuppression was predominantly calcineurin inhibitor (CNI, 22 patients).

Conclusion

Majority of MCD patients achieved remission, but over half relapsed within 6 months of initial remission. CNI is the most common adjunct treatment in our centre. Long term dialysis and death are uncommon.

Funding

  • Government Support – Non-U.S.