ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO608

Cardiovascular Risk Factor Burden and Treatment Control in Patients With CKD: The Fukuoka Kidney Disease Registry (FKR) Study

Session Information

Category: Hypertension and CVD

  • 1501 Hypertension and CVD: Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Kitamura, Hiromasa, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Tanaka, Shigeru, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Hiyamuta, Hiroto, Fukuoka Daigaku, Fukuoka, Fukuoka, Japan
  • Shimamoto, Sho, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Tsuruya, Kazuhiko, Nara Kenritsu Ika Daigaku, Kashihara, Nara, Japan
  • Nakano, Toshiaki, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
  • Kitazono, Takanari, Kyushu Daigaku, Fukuoka, Fukuoka, Japan
Background

Cardiovascular disease is a life-threatening complication of chronic kidney disease (CKD). Although cardiovascular risk factor management is important in patients with CKD, few reports detail the frequency of complications and the treatment of cardiovascular risk factors at different stages of CKD in clinical practice.

Methods

A total of 3,411 patients with non-dialysis-dependent CKD who participated in the Fukuoka Kidney disease Registry Study were cross-sectionally analyzed. Patients were classified into five groups based on their estimated glomerular filtration rate and urinary albumin to urinary creatinine ratio according to Kidney Disease: Improving Global Outcomes 2012 guidelines, which recommend low, moderate, high, very high, and extremely high-risk groups. The primary outcomes were the cardiovascular risk factor burden and the treatment status of cardiovascular risk factors. The association between the CKD groups and the treatment status of each risk factor was examined using a logistic regression model.

Results

The proportion of patients with hypertension, diabetes mellitus, and dyslipidemia increased significantly as CKD progressed, whereas the proportion of patients who achieved cardiovascular risk factor treatment targets was significantly decreased. In the multivariable analysis, the odds ratios (ORs) of uncontrolled treatment targets were significantly higher for hypertension (OR 7.43) and dyslipidemia (OR 1.45) in the extremely high-risk group than in the low-risk group.

Conclusion

Patients with non-dialysis-dependent CKD demonstrate an increased cardiovascular risk factor burden with CKD progression. Extremely high-risk CKD is associated with difficulty in managing cardiovascular risk factors.