ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO251

Association of Triglycerides to High-Density Lipoprotein Cholesterol Ratio With Incident Cardiovascular Disease but Not ESKD Among Patients With Biopsy-Proven Diabetic Nephropathy

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical

Authors

  • Uemura, Takayuki, Nara Medical University, Kashihara, Nara, Japan
  • Nishimoto, Masatoshi, Nara Medical University, Kashihara, Nara, Japan
  • Eriguchi, Masahiro, Nara Medical University, Kashihara, Nara, Japan
  • Tamaki, Hiroyuki, Nara Medical University, Kashihara, Nara, Japan
  • Tasaki, Hikari, Nara Medical University, Kashihara, Nara, Japan
  • Furuyama, Riri, Nara Medical University, Kashihara, Nara, Japan
  • Fukata, Fumihiro, Nara Medical University, Kashihara, Nara, Japan
  • Kosugi, Takaaki, Nara Medical University, Kashihara, Nara, Japan
  • Morimoto, Katsuhiko, Nara Prefecture Seiwa Medical Center, Ikoma, Nara, Japan
  • Matsui, Masaru, Nara Prefecture General Medical Center, Nara, Nara, Japan
  • Samejima, Ken-ichi, Nara Medical University, Kashihara, Nara, Japan
  • Tsuruya, Kazuhiko, Nara Medical University, Kashihara, Nara, Japan
Background

Increased triglycerides (TG) and decreased high-density lipoprotein cholesterol (HDL-C) are dyslipidemias characteristic of diabetes. Here, we aimed to examine the associations of TG/HDL-C ratio with subsequent cardiovascular disease (CVD) and kidney outcomes among patients with diabetic nephropathy.

Methods

A retrospective observational study consists of patients with biopsy proven diabetic nephropathy between June 1981 and December 2014. Patients complicated with other kidney diseases were excluded. Exposure of interest was TG/HDL-C ratio measured at the time of kidney biopsy. The outcome variables were kidney histological findings, incident CVD and end-stage kidney disease (ESKD). The association between TG/HDL-C ratio and histological findings was examined using logistic regression models. The association of TG/HDL-C ratio with incident CVD and ESKD was examined using Cox proportional hazard models.

Results

A total of 353 subjects were divided into quartiles based on TG/HDL-C ratio: Quartile 1 (reference), <1.96; Quartile 2, 1.96−3.10; Quartile 3, 3.11−4.55; and Quartile 4, ≥4.56. TG/HDL-C ratio was not a predictor of any histological findings in the fully adjusted model. During median follow-up periods of 6.2 and 7.3 years, 152 and 90 subjects developed incident CVD and ESKD, respectively. Higher TG/HDL-C ratio was independently associated with a higher incidence of CVD even after adjustments for potential confounders (hazard ratio (HR) [95% confidence interval (CI)] for Quartile 3 vs. reference; 1.73 [1.08−2.79] and Quartile 4 vs. reference; 1.86 [1.10−3.17]). Although there was a weak association between TG/HDL-C ratio and incident ESKD in the univariable model, the association was not significant in the fully adjusted model.

Conclusion

Among patients with biopsy-proven diabetic nephropathy, higher TG/HDL-C ratio was independently associated with a higher incidence of CVD. The effect of TG/HDL-C ratio on kidney dysfunction would be inconclusive, and further studies are now warranted.