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Abstract: SA-PO192

Associations of Calciprotein Particle Maturation Time With Echocardiographic Measures in the CRIC Study

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Authors

  • Sunderraj, Ashwin, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Cai, Xuan, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Pasch, Andreas, Calciscon AG, Biel, Switzerland
  • Feinstein, Matthew, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Mehta, Rupal, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Srivastava, Anand, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Ricardo, Ana C., University of Illinois Chicago UI Health, Chicago, Illinois, United States
  • Cohen, Debbie L., University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
  • Isakova, Tamara, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Background

Low T50 may indicate a high propensity for calcification. Low T50 is associated with severe coronary artery calcification (CAC) and CAC progression in patients with CKD. Vascular calcification is associated with left ventricular (LV) hypertrophy and ventricular dysfunction, but data on association of T50 with adverse echocardiographic outcomes are sparse. We examined associations of T50 with with LV mass, LV concentric remodeling, LV concentric hypertrophy, and LV eccentric hypertrophy in the Chronic Renal Insufficiency Cohort (CRIC) study.

Methods

Multivariable linear regression tested the cross-sectional association between year 1 T50 levels and LV mass. Multivariable logistic regression models tested the associations of T50 with concentric remodeling, concentric hypertrophy, and eccentric hypertrophy. Models were adjusted for age, sex, race, smoking status, BMI, systolic blood pressure, history of CVD, diabetes, eGFR and albuminuria.

Results

Among 2280 CRIC Study participants, at year 1, mean age was 59 ± 11years and mean eGFR was 43.2 ± 16.1ml/min/1.73m2. Mean LV mass was 105.7 ± 26.2g/m2, and LV concentric remodeling was present in 28.5%, LV concentric hypertrophy in 15.0%, LV eccentric hypertrophy in 36.3% of participants. One-SD lower T50 was associated with increased odds ratio (OR) of LV eccentric (OR = 1.37, 95% CI = [1.19 – 1.58]) and concentric (1.35 [1.20 – 1.52]) hypertrophy in unadjusted models; these associations were no longer statistically significant in fully adjusted models. In unadjusted models, one-SD lower T50 was associated with higher LV mass index (β = 3.04, 95% CI = [1.97 – 4.10]); this association was no longer statistically significant in fully-adjusted models. When we examined T50 in quartiles, the findings were similar.

Conclusion

Among the CRIC cohort, T50 was not associated with echocardiographic outcomes after multivariable adjustment.

Funding

  • Other NIH Support