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Abstract: TH-PO833

Effects of Curcumin Supplementation on mRNA Expression of NLRP3 Inflammasome, IL-1β, and NF-κB in Hemodialysis Patients

Session Information

Category: Health Maintenance‚ Nutrition‚ and Metabolism

  • 1400 Health Maintenance‚ Nutrition‚ and Metabolism


  • Mafra, Denise, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
  • Alvarenga, Livia De almeida, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
  • Ribeiro-Alves, Marcelo, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
  • Cardozo, Ludmila Fmf, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

Chronic Kidney Disease (CKD) patients have many complications associated with inflammation and oxidative stress. Inflammasomes are multimeric protein complexes that can be activated by the nuclear factor kappa-B (NF-κB). When the NLRP3 is activated, pro-Interleukin 1β (IL-1β) is cleavaged to IL-1β, inducing the inflammatory response. Curcumin may mitigate the inflammatory process.


Thirty-one patients with CKD on HD were randomized into two groups: “Curcumin” and “Control.” The curcumin group received 100 mL of orange juice with 12 g of carrots and 2.5 g of turmeric three times a week for three months. The control group received the juice with the same composition (without curcumin). The mRNA expression of NF-κB, NLRP3, and IL-1β was measured by real-time polymerase chain reaction (RT-qPCR) on PBMC.


Twenty-eight patients concluded the study, 14 patients in the control group [50% men, 51.5 (IQR=15.5) years, HD time 36 (IQR=38.75) months], and 14 patients in the curcumin group [50% men, 56.5 (IQR=20) years, HD time 45 (IQR=85) months]. After three months of supplementation with curcumin, the patients showed a significant reduction in mRNA expression of IL-1β (p=0.05) (Figure 1).


Curcumin supplementation showed to mitigate inflammation in CKD patients on HD by decreasing mRNA IL-1β expression.

Figure 1. Comparison of mRNA of the factors of evolution of the inflammatory pathway before and after three months of intervention


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