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Abstract: SA-PO238

Endurance Exercise Training Prevented the Progression of Diabetic Kidney Disease With Muscle Weakness in Type 2 Diabetic Animal Models With Obesity, Hypertension, and Hyperlipidemia

Session Information

Category: Diabetic Kidney Disease

  • 601 Diabetic Kidney Disease: Basic


  • Kotake, Hitoshi, St. Marianna University School of Medicine, Kawasaki, Japan
  • Sugaya, Takeshi, St. Marianna University School of Medicine, Kawasaki, Japan
  • Shibagaki, Yugo, St. Marianna University School of Medicine, Kawasaki, Japan
  • Ikemori, Atsuko, St. Marianna University School of Medicine, Kawasaki, Japan

The aim of this present study was to evaluate protective effects of endurance exercise training against diabetic kidney disease (DKD) with muscle weakness by using male spontaneously diabetic Torii (SDT) fatty rats as type 2 diabetic animal models with obesity, hypertension, and hyperlipidemia.


Eight-week-old SDT fatty rats (n = 12) and Sprague–Dawley (SD) rats (n = 10) were randomly divided into exercise (Ex; SDT-Ex: n = 6, SD-Ex: n = 5) and sedentary groups (SDT-Cont: n = 6, SD-Cont: n = 5), respectively. Each group underwent regular treadmill exercise four times a week from ages 8 to 16 weeks. After finishing the exercise protocol, the kidneys were isolated and leg muscle tissue was removed. The extracted muscle specimens were categorized as slow (soleus) or fast (EDL) muscle.


The exercise attenuated hypertension and hyperlipidemia and prevented increases in renal parameters levels without affecting of blood glucose levels. In the SDT fatty rats, it ameliorated renal morphological abnormalities in the interstitium of the surface and intermediate layers of the cortex. Downregulated expression of endothelial nitric oxide synthase in the glomerulus of the SDT fatty rats was significantly upregulated by the exercise. The exercise upregulated the renal expressions of both medium-chain acyl-CoA dehydrogenase and peroxisome proliferator-activated receptor γ coactivator-1α related to fatty acid metabolism. In addition, the exercise training increased the muscle strength and cross-sectional area of the type IIb muscle fibers in the EDL muscle, but not soleus muscle. The exercise training upregulated the protein expression of CD31, insulin receptor substrate-2, and phosphorylated endothelial nitric oxide synthase in the EDL muscle, suggesting acceleration of angiogenesis.


Endurance exercise training exerts reno-protective effects by preventing glomerular endothelial abnormality and enhancing renal fatty acid metabolism, and suppresses muscle weakness by acceleration of angiogenesis of EDL muscle, in type 2 diabetes with obesity, hypertension, and hyperlipidemia, independently of blood glucose.