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Abstract: TH-PO029

Serum Myo-Inositol Oxygenase Levels at Hospital Discharge Predict Progression to CKD in Community-Acquired AKI

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical‚ Outcomes‚ and Trials

Authors

  • Yadav, Ashok Kumar, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Kaur, Jaskiran, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Kamboj, Kajal, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Johal, Prabhjot Kaur, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Kundu, Monica, The George Institute for Global Health India, New Delhi, Delhi, India
  • Ghosh, Arpita, The George Institute for Global Health India, New Delhi, Delhi, India
  • Sethi, Jasmine, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Kumar, Vivek, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Jha, Vivekanand, The George Institute for Global Health India, New Delhi, Delhi, India
Background

Acute kidney injury (AKI) increases the risk of morbidity, mortality, and progression to chronic kidney disease (CKD). There are few data on the risk of CKD following community-acquired AKI (CA-AKI) and its predictors from developing countries. We evaluated the association of a panel of serum and urine biomarkers at the time of hospital discharge with 4-month renal outcome in CA-AKI.

Methods

Patients of either sex, aged between 18-70 years, with no underlying CKD, and with CA-AKI were recruited at the time of discharge from hospital. Levels of serum and urine biomarkers were analyzed and association between these markers and development of CKD, defined as eGFR <60 ml/min/1.73 m2 or dialysis dependence at 4 month after discharge, were analyzed using multivariate logistic regression analysis and penalized least absolute shrinkage and selection operator logistic regression.

Results

Out of a total 126 patients followed up for 4 months, 25 developed CKD. Those who developed CKD were older (p=0.008). Adjusted logistic regression showed that each 10% increase in standardized serum myo-inositol oxygenase (MIOX) level increased the odds of progression to CKD by 13.5%. With 10% increase in standardized urine Neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine and urine protein creatinine ratio (uPCR), increase in the odds of progression to CKD was 10.5%, 9.6% and 8%, respectively. Multivariable logistic model including serum MIOX, discharge serum creatinine and discharge uPCR, was able to predict the progression of CKD (Figure 1).

Conclusion

High level serum MIOX levels at the time of discharge from hospital are associated with progression to CKD in patients with CA-AKI.

Funding

  • Government Support – Non-U.S.