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Abstract: FR-PO777

25(OH)D- but Not 1,25(OH)2D- Is an Independent Risk Factor Predicting Graft Loss in Stable Renal Transplant Recipients

Session Information

Category: Transplantation

  • 2002 Transplantation: Clinical

Authors

  • Zeng, Shufei, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
  • Yang, Yide, Hunan Normal University, Changsha, Hunan, China
  • Li, Shuping, The Seventh Affiliated Hospital Sun Yat-sen University, Shenzhen, China
  • Chu, Chang, Universitatsklinikum Mannheim, Mannheim, Baden-Württemberg, Germany
  • Zheng, Zhihua, The Seventh Affiliated Hospital Sun Yat-sen University, Shenzhen, China
  • Krämer, Bernhard K., Universitatsklinikum Mannheim, Mannheim, Baden-Württemberg, Germany
  • Hocher, Berthold, Universitatsklinikum Mannheim, Mannheim, Baden-Württemberg, Germany
Background

Vitamin D deficiency (VDD) or vitamin D insufficiency is common in kidney transplant recipients (KTRs). The impact of VDD on clinical outcomes in KTRs remain poorly defined and the most suitable marker for assessing vitamin D nutritional status in KTRs is unknown so far.

Methods

We conducted a prospective study including 600 stable KTRs (367 men, 233 women) and a meta-analysis to pool existing evidence to determine whether 25(OH)D or 1,25(OH)2D predicted graft failure and all-cause mortality in stable KTRs.

Results

Compared with a higher 25(OH)D concentration, a low concentration of 25(OH)D was a risk factor for graft failure (HR 0.946, 95%CI 0.912-0.981, p=0.003), whereas 1,25 (OH)2D was not associated with the study end-point graft loss (HR 0.993, 95%CI 0.977-1.009, p=0.402). No correlation was found between either 25(OH)D or 1,25 (OH)2D and all-cause mortality. We furthermore conducted a meta-analysis including 8 studies regarding the association between 25(OH)D or 1,25(OH)2D and graft failure or mortality, including our study. The meta-analysis results were consistent with our study in finding that lower 25(OH)D levels were significantly associated with the risk of graft failure (OR=1.04, 95%CI: 1.01-1.07), but not associated with mortality (OR=1.00, 95%CI: 0.98-1.03). Lower 1,25(OH)2D levels were not associated with the risk of graft failure (OR=1.01, 95%CI: 0.99-1.02) and mortality (OR=1.01, 95%CI: 0.99-1.02).

Conclusion

Baseline 25(OH)D concentrations but not 1,25(OH)2D concentrations were independently and inversely associated with graft loss in adult KTRs.