Kidney Week

Abstract: TH-PO806

Urinary Sodium and Potassium and Blood Pressure in African and US Cohorts With CKD

Session Information

• Health Maintenance, Nutrition, Metabolism
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance‚ Nutrition‚ and Metabolism

• 1400 Health Maintenance‚ Nutrition‚ and Metabolism

Authors

• Ilori, Titilayo O., Boston University School of Medicine, Boston, Massachusetts, United States

Titilayo O. Ilori,

• Mamven, Manmak, University of Abuja, Abuja, Federal Capital Territory, Nigeria

Manmak Mamven,

• Solarin, Adaobi, Lagos State University College of Medicine, Ojo, Lagos State, Nigeria

Adaobi Solarin,

• Adebile, Temitayo M., Boston University School of Medicine, Boston, Massachusetts, United States

Temitayo M. Adebile,

• Raji, Yemi R., University College Hospital Ibadan, Ibadan, Oyo, Nigeria

Yemi R. Raji,

• Omotoso, Bolanle Aderonke, Obafemi Awolowo University College of Health Sciences, Ile-Ife, Osun, Nigeria

Bolanle Aderonke Omotoso,

• Ulasi, Ifeoma I., University of Nigeria, Nsukka, Enugu, Nigeria

Ifeoma I. Ulasi,

• Parekh, Rulan S., Women's College Hospital, Toronto, Ontario, Canada

Rulan S. Parekh,

• Gbadegesin, Rasheed A., Duke University School of Medicine, Durham, North Carolina, United States

Rasheed A. Gbadegesin,

• Zhao, Runqi, Boston University School of Medicine, Boston, Massachusetts, United States

Runqi Zhao,

• Amira, Christiana Oluwatoyin, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria

Christiana Oluwatoyin Amira,

• Adu, Dwomoa, University of Ghana Medical Centre, Accra, Accra, Ghana

Dwomoa Adu,

• Anderson, Cheryl A., University of California San Diego, La Jolla, California, United States

Cheryl A. Anderson,

• Ojo, Akinlolu, The University of Kansas Medical Center, Kansas City, Kansas, United States

Akinlolu Ojo,

• Waikar, Sushrut S., Boston University School of Medicine, Boston, Massachusetts, United States

Sushrut S. Waikar,

Background

Higher dietary sodium (Na) and lower potassium (K) are associated with increased blood pressure and cardiovascular disease risk. In individuals with CKD, there are conflicting results on the associations of dietary Na and K with kidney function. We examined associations of 24hr-urine Na and K, with systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) in Africans and Americans with CKD.

Methods

We analyzed 619 participants enrolled in an ancillary study to the Human Hereditary and Health in Africa Kidney Disease Network. Calibrated log transformed 24-hr urinary sodium (UNa), potassium (UK) and sodium/potassium ratio (UNa/UK) were analyzed centrally. Using generalized linear regression with a random intercept for clinical center, we calculated crude and adjusted (adjusting for covariates) β coefficients and 95% CI with each blood pressure parameter. Similar cross-sectional analyses were performed in the Chronic Renal Insufficiency Cohort (n=3459).

Results

Median UNa excretion was lower in West Africans vs Americans [134 (104-175) vs. 160 (118-215) mmol/24hr, p <0.001]. Median UK excretion was lower in West Africans vs Americans [36 (28-48) vs 55 (40-74) mmol/24hr (p <0.001)]. Higher UNa excretion was associated with higher SBP in both cohorts (Fig 1). Higher UK was associated with lower SBP, and significantly associated with lower DBP in both cohorts.

Conclusion

Cross-sectionally, higher urinary Na excretion, lower urinary K excretion and higher Na/K ratio are associated with higher blood pressure and is consistent among West Africans and Americans with CKD.

β Coefficients and 95% CI of UNa and K and Blood pressure

Funding

• NIDDK Support