Kidney Week

Abstract: SA-PO430

Association Between Sleep and COVID-19 Vaccination Response in Hemodialysis Patients

Session Information

• Hemodialysis and Frequent Dialysis: Clearance, Technology, Infection
  November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Han, Maggie, Renal Research Institute, New York, New York, United States

Maggie Han,

• Wang, Xiaoling, Renal Research Institute, New York, New York, United States

Xiaoling Wang,

• Ye, Xiaoling, Renal Research Institute, New York, New York, United States

Xiaoling Ye,

• Dong, Zijun, Renal Research Institute, New York, New York, United States

Zijun Dong,

• Thwin, Ohnmar, Renal Research Institute, New York, New York, United States

Ohnmar Thwin,

• Patel, Amrish U., Renal Research Institute, New York, New York, United States

Amrish U. Patel,

• Tisdale, Lela, Renal Research Institute, New York, New York, United States

Lela Tisdale,

• Wang, Lin-Chun, Renal Research Institute, New York, New York, United States

Lin-Chun Wang,

• Ren, Sarah, Renal Research Institute, New York, New York, United States

Sarah Ren,

• Rivera Fuentes, Lemuel, Renal Research Institute, New York, New York, United States

Lemuel Rivera Fuentes,

• Zhang, Hanjie, Renal Research Institute, New York, New York, United States

Hanjie Zhang,

• Kotanko, Peter, Renal Research Institute, New York, New York, United States

Peter Kotanko,

Background

Hemodialysis (HD) patients are less likely to mount a response to the COVID-19 vaccination (CoVac). Poor sleep is associated with blunted vaccination response in the general population. We aim to explore the association between CoVac and sleep quality (SQ) in HD patients.

Methods

Patients from 3 HD clinics were enrolled if they were ≥18 years and able to give written consent. Patients were administered the Insomnia Severity Index (ISI) and the Pittsburg Sleep Quality Index (PSQI). Blood specimen were collected after the primary series of COVID-19 vaccination. SARS-CoV-2 neutralization antibodies (nAB) were assayed using the GenScript SARS-CoV-2 Surrogate Virus Neutralization Test Kit (Cat#L00847-A). nAB titers are presented as Unit/ml on a natural log scale. PSQI scores of >5 were categorized as poor SQ and ≤5 as good SQ. ISI scores were grouped as no clinically significant insomnia (NI; score 0-7), subthreshold insomnia (SI; score 8-14), and clinical insomnia (CI; score 14-28). T-test and ANOVA analysis were performed on PSQI and ISI scores, respectively, to determine the statistical association between SQ and nAB levels

Results

58 patients were included (60±9 years old, HD vintage 4.7±4.5 years, 62% male, 66% Black, 21% Hispanic). In the PSQI, 72% (n=42) had poor SQ. In the ISI, 52% = NI, 31% = SI, and 17% CI. Box plots of nAB levels with median and IQR are shown in Fig. 1. There is no association between SQ and nAB levels.

Conclusion

There is no association between SQ and CoVac response. Given the immune dysfunction in this population, any modifying effect SQ has on CoVac, as observed in the general population, is unlikely. Other methods of improving CoVac response in this vulnerable population should be explored.

Funding

• Commercial Support – Renal Research Institute