ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: TH-OR30

Prevalence and Persistence of CKD and Hypertension 36 Months Post-Cisplatin in Children

Session Information

Category: Pediatric Nephrology

  • 1800 Pediatric Nephrology


  • McMahon, Kelly, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
  • Iyengar, Yajur, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada
  • Lebel, Asaf, SickKids Research Institute, Toronto, Ontario, Canada
  • Cockovski, Vedran, SickKids Research Institute, Toronto, Ontario, Canada
  • Wang, Stella Qiongbin, SickKids Research Institute, Toronto, Ontario, Canada
  • Zappitelli, Michael, SickKids Research Institute, Toronto, Ontario, Canada

Group or Team Name

  • ABLE Nephrotoxicity Group

Long-term kidney outcomes in children treated with Cisplatin(CisP) are unclear. We 1)estimated low eGFR and elevated BP or hypertension(eBP-HT) prevalence 36 months(m) post- pediatric CisP therapy; 2) determined if a)AKI during CisP and b)3m and 12 m kidney and BP status were associated with 36m low eGFR and eBP-HT.


12 Canadian-site 36m prospective cohort study of CisP-treated children. Exposures: a) AKI during CisP therapy (KDIGO serum creatinine criteria); b) 3m and 12m low eGFR (<90ml/min/1.73m2) and eBP-HT. 36m outcomes: a) low eGFR; eBP-HTN. Univariate tests and logistic regression (odds ratios [OR], 95% CI) were used to evaluate exposure-outcome associations.


101 participants (51.5% girls, median[IQR] age 4.4[2.4-9.2]) included. 36m post CisP: 16/85(18.8%) had low eGFR; 26/88(29.6%) had eBP-HT; 38/79 patients(48.1%) had low eGFR or eBP-HT. Table 1 shows characteristics by outcomes. AKI was associated with 36m composite low eGFR or eBP-HTN (AKI: 23/38[60.5%]; no AKI: 15/38[39.5%], p<0.05). Low eGFR at 3m and 12m post-CisP were associated with 36m low eGFR (OR[95% CI]: 17.5[1.7-183]; 16[1.5-167], respectively, Table 1). 12m eBP-HT was associated with 36m eBP-HT (OR [95% CI] 4[1.4-11.8], Table 1). 12m low eGFR or eBP-HT was associated with 36m low eGFR or eBP-HT (OR [95% CI] 3.0 [1.1-8.3]).


Low eGFR and high BP are common after CisP and persist from 3m and 12m to 36m. Clear post-CisP kidney health follow-up guidelines must be developed. AKI during therapy may portend worse long-term CisP kidney health.

* p-value <0.05; ** p-value<0.01; # In the month prior to the 36 months’ follow-up visit. Continuous variables expressed as median [interquartile range]; categorical variables expressed as numbers (proportion of total).