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Abstract: FR-PO938

Relationship of Light-Intensity and Moderate-to-Vigorous Intensity Physical Activity Habits for Kidney Dysfunction: A General Population Cohort Study

Session Information

Category: CKD (Non-Dialysis)

  • 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Sakurai, Goro, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Toyama, Tadashi, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Hara, Akinori, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Yamamura, Yuta, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Nakagawa, Shiori, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Oshima, Megumi, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Miyagawa, Taro, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Ogura, Hisayuki, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Kitajima, Shinji, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Sakai, Norihiko, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Shimizu, Miho, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Wada, Takashi, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan
  • Iwata, Yasunori, Kanazawa Daigaku, Kanazawa, Ishikawa, Japan

Group or Team Name

  • Department of Nephrology and Laboratory Medicine, Kanazawa University
Background

There are limited studies considering exercise intensities and their frequencies in relation to kidney dysfunction.

Methods

A community-based historical cohort study was conducted including Japanese general people aged ≥ 40 years. Participants were divided into four categories according to the combination of their exercise habits: regular light-intensity physical activity (R-LPA: 1.5 to 3.0 metabolic equivalents [METs] at least 60 minutes a day) and occasional moderate-to-vigorous physical activity (O-MVPA: > 3.0 METs at least 30 minutes twice a week). The outcome was the incidence of a 40% decrease in estimated glomerular filtration rate (eGFR) from baseline. Cox proportional hazards models were used to examine the association of exercise habits.

Results

A total of 72,999 people were included. During the mean follow-up of 5.9 years, 2,989 (4.1%) participants achieved the outcome. Compared to the people with neither R-LPA nor O-MVPA, the adjusted hazard ratios were 0.94 (95% CI: 0.85, 1.03; p = 0.182) for R-LPA alone, 0.97 (95% CI: 0.85, 1.10; p = 0.618) for O-MVPA alone, and 0.83 (95% CI: 0.76, 0.91; p < 0.001) for a combination of R-LPA and O-MVPA. There was a significant interaction between sex and exercise habits.

Conclusion

In general people, a combination of R-LPA and O-MVPA was associated with a lower risk of kidney dysfunction compared with no exercise habit. Future studies are warranted to determine the exercise intensity and duration that protects kidney function.