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Abstract: FR-PO802

Serum and Urine Uromodulin, Kidney Volume, and Function in Living Kidney Donors

Session Information

Category: Transplantation

  • 2002 Transplantation: Clinical

Authors

  • Erdut, Arda, Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
  • Jabrayilov, Jabrayil, Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
  • Önal, Ceren, Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
  • Uzerk Kibar, Muge, Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
  • Hazirolan, Tuncay, Hacettepe University Faculty of Medicine, Department of Radiology, Ankara, Turkey
  • Bozaci, Ali Cansu, Hacettepe University Faculty of Medicine, Department of Urology, Ankara, Turkey
  • Yildirim, Tolga, Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
  • Altun, Bulent, Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
  • Aki, Fazil Tuncay, Hacettepe University Faculty of Medicine, Department of Urology, Ankara, Turkey
  • Arici, Mustafa, Hacettepe University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
Background

Uromodulin is an indicator of nephron mass and tubular function.This study has investigated the relationship between serum uromodulin (Sumod), urine uromodulin (Uumod) and remaining kidney volume and function in living kidney donors (LKD).

Methods

One hundred LKD (Mean age 52.46 ± 10.38, 65 women, average follow-up 63.23±56.82 months) were included in the study. Kidney volumes were assessed by preoperative abdominal computed tomography and by magnetic resonance imaging at the last clinic visit. Uromodulin levels were measured in blood and urine by uromodulin human ELISA kit.

Results

There was a correlation between Sumod and glomerular filtration rate (GFR) (r=0.29, P=0.006), creatinine (r=-0.25, P=0.02) and age (r=-0.36, P<0.001) (Table 1). 16 donors had chronic kidney disease (CKD) during the follow up. Sumod levels of 16 patients with CKD was lower than those without CKD (78.12±34.19 vs. 94.03±32.55 ng/ml, P=0.047). A strong correlation between Uumod and GFR was found in patients with CKD (r=0.64, P=0.007). Uumod level changed in parallel with the follow-up period (r=0.28, P=0.006). A negative correlation between Uumod and proteinuria difference was demonstrated (r=-0.32, P=0.002). The remaining kidney was found to be enlarged by 22% (Table 2). The increase in volume correlated with GFR (r=0.34, P=0.001) and follow-up time (r=0.37, P<0.001). There was no relationship among Sumod, Uumod and remaining kidney volume.

Conclusion

Kidney function in LKD were associated with Sumod, Uumod and remaining kidney volume. Uumod was a better indicator of kidney function in donors who developed CKD.

Funding

  • Government Support – Non-U.S.