ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: FR-PO879

Transplantation Outcome Racial Disparities in Autosomal Dominant Polycystic Kidney Disease

Session Information

Category: Diversity and Equity in Kidney Health

  • 800 Diversity and Equity in Kidney Health

Authors

  • McGill, Rita L., University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States
  • Chapman, Arlene B., University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States
Background

Autosomal dominant polycystic kidney disease (ADPKD) patients access to pre-emptive and living donor transplantation varies by race throughout the United States. In this analysis, we examined transplant outcomes by race among patients with ADPKD.

Methods

OPTN/UNOS files were used to identify patients age>=30 with ADPKD who received kidney-only transplants. Race was stratified as White (W), African American (AA), Hispanic (H), and Asian (A). Cox models were used to calculate hazard ratios (HR) for graft failure, using (W) as the reference. The model was then adjusted for age, sex, BMI, cold ischemia time, living donation, pre-emptive transplant, diabetes, use of induction therapy, steroid maintenance, and HLA mismatch.

Results

30898 ADPKD transplant recipients were assessed. Patient characteristics are outlined in Table 1. The unadjusted HR for graft failure among AA was 1.55 (1.45, 1.66) P<0.001, and remained 1.30 (1.20, 1.41) P<0.001 after adjustment. Outcome disparities were not observed among H or A patients with ADPKD. (Table 2)

Conclusion

African American ADPKD patients are at higher risk for graft failure after kidney transplant than other patients, above and beyond reduced access to living donor and pre-emptive transplantation. Further work is needed to determine what remediable factors could lead to more equity in transplant outcomes.