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Abstract: FR-PO833

Kidney Transplantation Is Significantly Associated With Severe Herpes Zoster Infection: A Nationwide Population-Based Cohort Study With Propensity Score Matching Analysis

Session Information

Category: Transplantation

  • 2002 Transplantation: Clinical

Author

  • Yu, Tung-Min, Taichung Veterans General Hospital, Taichung, 407, Taiwan
Background

Kidney organ recipient has been considered to be on immunosuppression lifelong and that is suggested to be likely associated with various infection diseases including virus infection. We conducted a nationwide population-based cohort study to investigate the risk of herpes virus infection in this population.

Methods

From the Taiwan National Health Insurance Research Database (NHIRD) records, individuals hospitalized as solid organ recipients including kidney recipients were defined as a case group of solid organ transplantation (SOT) patients and matched with a non-SOT cohort.

Results

A total of 18748 individuals , namely 9374 (50%) with (case) and 9374 (50%) without a medical SOT record (comparison) were enrolled. Because the patients were propensity score matched according to gender, age, index year, and
comorbidities, no significant difference was observed between the case and comparison groups for these factors.
We classified SOT as kidney, heart, lung, liver, bone, or pancreas transplantation. Compared with patients without SOT, patients with kidney (aHR = 9.07, 95% CI = 6.84–12.03), heart (aHR = 13.95, 95% CI = 8.63–22.57), lung (aHR = 48.47, 95% CI = 21.03–111.73), liver (aHR = 6.03, 95% CI = 4.15–8.75) transplantation had a significantly higher risk of HZ after adjustment for demographic factors and comorbidities.

Conclusion

In the present study, our findings disclose that renal transplant recipient was significantly associated with remarkably high risk of herpes aplha virus infection including herpes simplex virus which was neglected previously . For clinical practice, professionals should maintain high index of suspicion in patients with kidney transplantation.