Abstract: TH-PO241
Nesfatin-1 and Tubulointerstitial Damage in Diabetic Kidney Disease: A Possible Biomarker for the Histological Severity
Session Information
- Diabetic Kidney Disease: Clinical - I
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 602 Diabetic Kidney Disease: Clinical
Authors
- Miyake, Sayoko, Kinki Daigaku Byoin, Osakasayama, Osaka, Japan
- Nakatani, Yoshihisa, Kinki Daigaku Byoin, Osakasayama, Osaka, Japan
- Nakano, Yukihito, Kinki Daigaku Byoin, Osakasayama, Osaka, Japan
- Arima, Shuji, Kinki Daigaku Byoin, Osakasayama, Osaka, Japan
Background
Although adipokines are known to contribute to the pathogenesis of diabetic kidney disease (DKD), pathological significance of nesfatin-1, an adipokine in DKD remains unclear. We studied the possible associations between serum nesfatin-1 concentrations and histological renal damages in 56 persons with biopsy-proved DKD.
Methods
The relation between serum nesfatin-1 concentrations, clinical parameters and renal histological damage were cross-sectionally investigated. The relation between serum nesfatin-1 concentrations and renal outcomes were also examined longitudinally.
Results
Serum nesfatin-1 concentrations showed a significant negative correlation with age, total cholesterol, and high-density lipoprotein cholesterol, but not with other clinical parameters. Persons were divided into the following three groups based on serum nesfatin-1 concentrations (pg/mL): low- (log average: 1.99), normal- (log average: 3.05), and high-group (log average: 3.60). Histological analysis of tubulointerstitial lesions showed higher interstitial fibrosis and tubular atrophy scores and more severe interstitial infiltration in the group with low serum nesfatin-1 concentrations than in the other groups. However, there was no significant relation between serum nesfatin-1 concentrations and the severity of glomerular lesions nor renal outcomes.
Conclusion
Serum nesfatin-1 concentrations showed a strong correlation with diabetic tubulointerstitial damage level, suggesting its clinical utility as a biomarker for histological injury in DKD.