Abstract: FR-PO745
Triglyceride-Glucose (TyG) Index Is an Independent Predictor of the Coronary Artery Calcification Progression in CKD Patients
Session Information
- Hypertension and CVD: Clinical, Outcomes, Trials
November 04, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1502 Hypertension and CVD: Clinical‚ Outcomes‚ and Trials
Authors
- Ko, Ye Eun, Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
- Koh, Hee Byung, Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
- Jhee, Jong Hyun, Division of Nephrology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Yoo, Tae-Hyun, Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea (the Republic of)
Background
There have been few studies about the relationship between triglyceride-glucose (TyG) index, which is known to be related to insulin resistance, coronary artery calcification (CAC) progression, and increase in cardiovascular events in general population. The aim of this study is to investigate the association between TyG index and CAC progression in CKD patients.
Methods
A total of 1,154 CKD (stage 1 to 5) patients were enrolled from the nationwide multicenter prospective observational cohort of KNOW-CKD (KoreaN Cohort Study for Outomes in Patients With Chronic Kidney Disease). TyG index was calculated as follows: ln(fasting triglycerides x fasting glucose/2). The patients were classified into tertile (low, intermediate, high) based on TyG index. The CAC density score was calculated by dividing the Agatston score by the total area score. Primary outcome was annualized percentage change in CAC score: (percent change in CAC score + 1)＾(12/follow-up months)-1, of ≥15%, which was defined as CAC progression.
Results
The mean age of study subjects was 52.8±11.9 years and 688(59.6%) were male. During 4 year follow-up, annualized percentage change in CAC score was 16.7± 34.7, 20.8± 39.4, 24.9± 38.5 in low, intermediate, high TyG index respectively. Percentage of patient with CAC progression showed stepwise increasing pattern across TyG index group (28.6%, 37.5%, 46.2% in low, intermediate, high TyG index group in order; P<0.001). In multivariate logistic regression analysis, the high TyG index group was associated with increased risk of CAC progression (OR, 1.48; 95% CI, 1.01-2.16; P=0.04) compared to low TyG index group. Moreover, 1 increase in TyG index was related to increased risk of CAC progression (OR, 1.34; 95% CI, 1.06-1.76; P=0.02) after adjusting confounding factors.
Conclusion
High TyG index may be useful predictor of CAC progression in CKD patients.