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Abstract: SA-PO163

Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical


  • Naiyaraksaeree, Nuanjanthip, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Phannajit, Jeerath, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Naiyarakseree, Wichai, The Bangkok Christian Hospital, Bangkok, Bangkok, Thailand
  • Lekhyananda, Sookruetai, Kidney Foundation of Thailand, Bangkok, Bangkok, Thailand
  • Avihingsanon, Yingyos, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Praditpornsilpa, Kearkiat, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Eiam-Ong, Somchai, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Susantitaphong, Paweena, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand

Vitamin K deficiency is one of the most important risk factors of vascular calcification and arterial stiffness in chronic kidney disease and dialysis patients. However,the benefit of vitamin K supplementation on structural and functional vascular health are still not established. This study was aimed to evaluate the efficacy of menaquinone-7 (MK-7) supplementation on arterial stiffness in chronic hemodialysis (HD) patients.


This open-label multicenter randomized clinical trial was conducted in 96 HD patients who had arterial stiffness, defined by high carotid femoral pulse wave velocity (cfPWV ≥ 10 m/s). The patients were randomly assigned to receive oral MK-7 (375 mcg once daily) for 24 weeks (n = 50) or standard care (control group; n = 46). The change of cfPWV was evaluated as primary outcome.


The baseline parameters were comparable between two groups. At 12 weeks, patients who received MK-7 had a trend in decreasing in cfPWV compared with standard care (-13.0 ± 20.7% vs -6.8 ± 21.1%, p=0.18). This effect is more prominent in diabetes patients (-9.9±13.8% vs 1.9±17.2%, p = 0.065), In addition, the MK-7 group had lower rate of arterial stiffness progression compared with control group (21.4% vs 34.1%, p = 0.20), especially in diabetes patients (21.4% vs 58.3%, p = 0.054). There were no serious adverse events observed during 12 weeks.


Vitamin K supplementation provided a trend in decreasing arterial stiffness at short term follow up without serious adverse effects, especially patients with diabetes. However, the benefit on vascular heath and cardiovascular outcomes are still needed.


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