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Abstract: TH-PO696

Potential Long-Term Economic Benefits of Switching From Epoetin Alfa to Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PH) Inhibitors for the Management of Anemia in Hemodialysis (HD) Patients

Session Information

  • Anemia and Iron Metabolism
    November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
    Abstract Time: 10:00 AM - 12:00 PM

Category: Anemia and Iron Metabolism

  • 200 Anemia and Iron Metabolism

Authors

  • Funakoshi, Satoshi, Nagasaki Kidney Center, Nagasaki, Nagasaki, Japan
  • Yamaguchi, Kosei, Nagasaki Kidney Center, Nagasaki, Nagasaki, Japan
  • Kitamura, Mineaki, Nagasaki Kidney Center, Nagasaki, Nagasaki, Japan
  • Nishino, Tomoya, Nagasaki Daigaku Igakubu Daigakuin Ishiyakugaku Sogo Kenkyuka, Nagasaki, Nagasaki, Japan
Background

HIF-PH inhibitors, which have recently become clinically available for treating renal anemia, are attracting attention for their novel mechanisms of action. However, the cost of the starting dose of HIF-PH inhibitors is considerably higher than EPO, and it may limit the use of them. Since HIF-PH inhibitors potentially lead to the activation of numerous HIF-regulated genes,
we expected savings in drug use due to improvements in physical condition (i.e. cardiovascular protection) other than direct hematopoietic effects when used over the long term.

Methods

Sixty-four HD patients treated with 9000 U/week of EPO were converted to roxadustat (Rox) three times a week at a dose of 100 mg, then dose of Rox was titrated to achieve Hb level between 10 to 12 g/dL. In a similar way sixty-one HD patients treated with 9000 U/week of EPO were converted to daprodustat (Dap) at daily dose of 6 mg, then dose of Dap was titrated to achieve Hb level between 10 to 12 g/dL.

Results

The starting amounts of Rox and Dap were approx. 4,100 and 3,000 JPY / week, respectively, while EPO was approx. 2,600 JPY / week. AS shown in Figure, while spending on EPO naturally remained unchanged, but the respective drug use of Rox and Dap slowly decreased and the costs became almost equivalent to the cost of EPO in one year.

Conclusion

We have shown that administering Rox and Dap, HIF-PH inhibitors, had led to a reduction in cost in long-term use. Given the cost sparing advantages HIF-PH inhibitors as has been reported, they appear to be an effective alternative to ESA in the long-term management of anemia in HD patients.

Funding

  • Private Foundation Support