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Abstract: TH-PO591

Childhood Systolic Blood Pressure Predicts Hypertension in Young Adults: A 10-Year Follow-Up Study of Icelandic Children

Session Information

Category: Hypertension and CVD

  • 1501 Hypertension and CVD: Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Sigurdardottir, Asdis H., Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
  • Indridason, Olafur S., Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
  • Hrafnkelsdottir, Thordis J., Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
  • Stephensen, Sigurdur S., Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
  • Edvardsson, Vidar O., Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
Background

Although there is significant evidence for an association between childhood and adult clinic blood pressure (BP), data on the association of childhood BP and ambulatory BP (ABP) and hypertension in young adults are missing. The aim of this study was to examine the predictive value of childhood BP for ambulatory HTN in young adults.

Methods

Subjects were recruited from a cohort of 970 adults aged 20-22-years who participated in a population-based study of BP in 9-10-year-old Icelandic children. All participants underwent 4 resting BP measurements in childhood and the follow-up study included both clinic and ABP measurements. The 2017 AHA guideline was used to define HTN at follow-up and the fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents was used to define childhood BP percentiles. Logistic regression analysis was used to examine the relationship between childhood BP and HTN at follow-up.

Results

A total of 163 individuals, 66 (40%) men, participated in the follow-up study. At follow-up a total of 40 (24%) participants had HTN, of those 37 (23%) had ambulatory HTN, 11 had both clinic and ambulatory HTN and 3 had white-coat HTN only. There was an independent association between HTN at follow-up and absolute childhood systolic BP (SBP) (OR 1.08, CI95% [ 1.02 – 1.15]). Men were more likely to have HTN than women at follow-up (OR 3.00, CI95% [ 1.4 – 6.6], p<0.001). Men were also more likely than women to have ambulatory HTN at follow-up (OR 2.39, CI95% [ 1.12 – 5.25], p <0.05). One mm Hg increase in SBP at the age of 9-10 years was associated with a
10% rise in the probability of ambulatory HTN at age 20-22 years (OR 1.10, CI95% [ 1.01 – 1.21], p <0.05). Individuals with SBP >90th percentile were three times more likely to have ambulatory HTN (OR 3.4, CI95% [ 1.5 – 7.68], p <0.001) at follow-up. Diastolic BP (DBP) and body mass index (BMI) percentiles at the age of 9-10 years predicts neither clinic nor ambulatory HTN at the age of 20-22 years.

Conclusion

Male sex and SBP indices at the age of 9-10 years predicts both clinic and ambulatory HTN in young adults.

Funding

  • Government Support – Non-U.S.