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Abstract: SA-PO324

Characteristics of US Individuals With Cystic Fibrosis and ESRD

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis


  • Stevanovic, Mirjana, Dartmouth Guarini School of Graduate and Advanced Studies, Hanover, New Hampshire, United States
  • Graber, Martha L., Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, United States

Persons with cystic Fibrosis (CF) have increased rates of diabetes, lung transplantation, acute kidney injury (AKI), and chronic kidney disease (CKD). Data are lacking concerning the prevalence and outcomes of end stage renal disease (ESRD) in this population


We analyzed data from the US Renal Data System (USRDS) for the years 2014-2018 inclusive


Baesd on population prevalence individuals with CF have a 10-20 fold rate of ESRD compared with the general population (USRDS 2016 data).

Prevalent individuals with CF and ESRD were significantly younger (41.8 vs 59.5 years), had lower BMI, were more likely to be White and female, to initiate renal replacement therapy with peritoneal dialysis or transplantation, and to receive a living donor kidney. There was no significantly increased risk of death in a five year period.


The characterisitcs of US individuals with CF and ESRD have not been previously described. Relative to the general US population persons with CF have a markedly increased (10-20-fold) risk of developing ESRD. We describe the demographic characteristics of these individuals, who are younger, more likely to be White and female and more likely to start renal replacement therapy with peritoneal dialysis or transplantation and to receive a living donor kidney than those without CF. These findings have important implications for awareness, management, and prevention of AKI and CKD in this vulnerable population.

Details of etiologies of ESRD in CF are submitted in a separate abstract.


  • NIDDK Support