Abstract: SA-PO323
Primary Causes of ESRD in the US Cystic Fibrosis Population
Session Information
- Hemodialysis and Frequent Dialysis: Potpourri
November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Stevanovic, Mirjana, Dartmouth Guarini School of Graduate and Advanced Studies, Hanover, New Hampshire, United States
- Graber, Martha L., Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, United States
Background
We have previously shown that individuals with with cystic fibrosis (CF) have a greater than ten fold risk of end stage renal disease (ESRD) relative to the general population. Persons with CF have higher rates of AKI and CKD, higher rates of lung and other organ transplantation, and an approximately 40% risk of developing diabetes. However, the roles of diabetes and other possible etiological risk factors for ESRD in CF are not defined
Methods
We analyzed data from the US Renal Data System (USRDS) 2014-2018 inclusive
Results
Non-type I diabetes was the leading cause of ESRD in the age-adjusted CF population, but was significantly less frequent compared to the general ESRD population. There was no difference in the age-adjusted frequency of type I diabetes as a cause of ESRD.
The second and third most frequent causes of ESRD in CF were complications of lung transplant, and nephropathy due to drugs and other agents respectively. Hypertension was significantly less frequent in the CF population. There was no difference in the rates of glomerulonephritis and cystic diseases.
Conclusion
Individuals with CF have a greater than ten-fold risk of developing ESRD compared to the general US population. Non-type I diabetes mellitus is the leading casue of ESRD in CF, however diabetes is approximately 50% less frequent an etiology than in the general ESRD population. Complications of lung transplantation and medication toxicities are additional important etiologies in CF, rarely identified in the non-CF population. Glomerulonephritis was no more common as an etiology amongst CF individuals than those without CF, and hypertension was significantly less frequently identified as the casue of ESRD. Our future studies aim to identify more specificity within these categories and to evaluate the impact of CFTR activating agents.
Demographic characteristics of CF persons with ESRD are described in a separate abstract submission to this meeting
Funding
- NIDDK Support