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Abstract: SA-PO360

Muscle Sodium (Na+) Reduction by 2-Month Low-Na+ Diet in Hemodialysis (HD) Patients

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Fang, Hsin-Yu, University of Illinois System, Urbana, Illinois, United States
  • Jung, Kwan-Jin, University of Illinois System, Urbana, Illinois, United States
  • Kwan, Shu H., University of Illinois System, Urbana, Illinois, United States
  • Morgan, Ashley, University of Illinois System, Urbana, Illinois, United States
  • Damore, Bailey J., University of Illinois System, Urbana, Illinois, United States
  • Wilund, Kenneth Robert, University of Illinois System, Urbana, Illinois, United States
Background

Skeletal muscle is a tissue Na+ reservoir. Higher muscle Na+ concentration ([Na+]) is associated with pathological conditions in HD patients. This study aimed to test if 2 months of low-Na+ intervention reduces muscle [Na+] in HD patients.

Methods

Eight HD patients (75% male; 61±11 yr) received commercial low-Na+ meals and dietary counseling for 2 months. Meal provision frequencies for month 1 and 2 were 2 and 1 meal/day, respectively. Pre- and post-meal muscle [Na+] were assessed by 3T 23Na-MRI on non-HD days in 6 muscles: tibialis anterior (TA), extensor digitorum longus (EDL), peronei (PER), soleus (SOL), and lateral (LG) and medial (MG) gastrocnemius. Total 23Na-MRI signals were split into intracellular (IC) and extracellular (EC)-weighted signals by biexponential fitting for further analysis. Changes in variables were tested by paired t-test or nonparametric equivalents.

Results

Muscle [Na+] was reduced in LG (P=.008) and MG (P=.02) but unchanged (P>.05) in other muscles from pre- to post-intervention (Fig. 1). IC-weighted 23Na-MRI signal was reduced after intervention in 50% of muscles, while EC-weighted signal remained stable in all muscles tested (P-values shown in Fig. 2).

Conclusion

We found that the [Na+] in some muscles were decreased after the 2-month low-Na+ diet, which may reflect more of the change in IC-weighted 23Na signal. More studies are needed to confirm this and to determine its clinical implication.

Fig 1. Pre- to Post-Meal Changes in Muscle [Na+].

Fig 2. Changes in Intracellular (IC) and Extracellular (EC)-Weighted 23Na-MRI Signals in Muscles.

Funding

  • Private Foundation Support