Abstract: TH-PO812
Selenium Concentration and Kidney Function: A Mendelian Randomization Study
Session Information
- Health Maintenance, Nutrition, Metabolism
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance‚ Nutrition‚ and Metabolism
- 1400 Health Maintenance‚ Nutrition‚ and Metabolism
Authors
- Park, Sehoon, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Kim, Yong Chul, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Han, Seung Seok, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Lee, Hajeong, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Kim, Yon Su, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Kim, Dong Ki, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
Background
Selenium is one of the trace minerals that is commonly included in micronutrient supplements, although the supplementation is associated with some adverse side effects. The effect of selenium on kidney function remains unclear. A genetically predicted micronutrient and its’ association between eGFR can be used to assess the causal estimates towards kidney function by Mendelian randomization (MR).
Methods
In this MR study, we instrumented 11 genetic variants associated with blood or toenail selenium level with genome-wide significance from a previous large-scale genome-wide association study (GWAS). The association between genetically predicted selenium concentration and eGFR was first assessed by summary-level MR in the CKDGen GWAS meta-analysis summary statistics including 567,460 European samples. Replication analysis was performed with individual-level UK Biobank data including 337,318 white British ancestry individuals.
Results
Summary-level MR analysis by inverse variance weighted method indicated that a genetically predicted one standard deviation increase in selenium concentration was significantly associated with low eGFR [-1.05 (-1.28, -0.82) %]. The results were similarly reproduced by pleiotropy-robust MR analysis including MR-Egger and weighted median method. In the UK Biobank data, genetically predicted high selenium concentration was also significantly associated with low eGFR [-0.36 (-0.52, -0.20) %], and the results were similar when body mass index, hypertension, and diabetes mellitus covariates were adjusted [-0.33 (-0.50, -0.17) %].
Conclusion
This MR study suggests higher concentration of selenium may possibly decrease eGFR for a small degree. Selenium should be carefully supplemented for those at risk of kidney function impairment.