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Abstract: SA-PO168

Lipid Profile Increased the Risk of Incident Kidney Stones in a Population-Based Cohort Study

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical


  • Fan, Xiaohong, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China
  • Ma, Jie, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China
  • Li, Xuemei, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

The prevalence and incidence rate of kidney stones has increased in the past ten years in China. The kidney stone was associated with metabolic diseases such as hypertension, diabetes, and obesity and is also considered to be a higher risk factor for cardiovascular diseases. However, the association between lipid profile and kidney stones has not been thoroughly examined in the Chinese population.


We performed a retrospective cohort study in the Department of Health and Medicine in Peking Union Medical College Hospital from January 2014 to December 2021. Thirty-three thousand nine hundred ninety-nine subjects having repeat physical examinations with an interval of 5 years or more were enrolled. Renal ultrasonography was used to define the presence of kidney stones. Lipid profiles such as triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL_C), low-density lipoprotein cholesterol (LDL_C), and TC/HDL ratio were categorized by lipid profiles quartiles.


26,594 subjects were included in the final analysis, and the mean age was 40.9±12.5years; 50.4% were males. All subjects were followed for 71.5±11.4 months. The prevalence rate of renal ultrasound confirmed kidney stones at baseline was 1.33%, and the incident rate was 289.6 cases per 100,000 person-years. The incident rate increased with the higher quartiles of lipid profiles such as TC, TG, LDL_C, and TC/HDL_C (P for trend<0.01) but decreased with higher quartiles of HDL_C (P for trend<0.001). After adjusting for age, gender, body mass index, estimated glomerular filtration rate, hypertension, and diabetes, the subjects with quartile 4 of TC/HDL_C (>4.26) had a 1.415-fold higher risk of incident kidney stone formation compared to those with quartile 1; quartile 4 of HDL_C (>1.65mmol/L) was significantly associated with decreased risk of incident kidney stones (HR 0.563, 95%CI 0.407-0.778).


In the present cohort study, a higher level of TC/HDL_C showed a significantly increased risk of incident kidney stones, and higher HDL_C protected against developing kidney stones. The management of dyslipidemia maybe contributes to a lower risk of kidney formation.