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Kidney Week

Abstract: TH-PO110

Non-Pharmacological Interventions in Chronic Non-Communicable Diseases: The Impact of Moderate Physical Exercise in Rats

Session Information

  • AKI: Mechanisms - I
    November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
    Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

  • 103 AKI: Mechanisms

Authors

  • Vattimo, Maria de Fatima F., Universidade de Sao Paulo, Sao Paulo, Brazil
  • Silva, Eloiza Oliveira, Universidade de Sao Paulo, Sao Paulo, Brazil
  • Ventura, Sara, Universidade de Sao Paulo, Sao Paulo, Brazil
  • Oliveira, Brenner Kássio, Universidade Federal do Amazonas, Manaus, AM, Brazil
  • Victoria, Carla djamila de Pina, Universidade de Sao Paulo, Sao Paulo, Brazil

Group or Team Name

  • Research Group on Experimental Acute Kidney Injury
Background

Chronic non-communicable diseases (NCDs) are the most relevant cause of premature deaths and morbidities. The goal of the World Health Organization is to reduce NCDs by 25% by 2025. Among the complications of NCDs, chronic kidney disease (CKD) and acute kidney injury (AKI) stand out. The physical exercise (E) is a non-pharmacological intervention that suppress the morbidity of CKD and DM. This study aims to evaluate the effect of the moderate aerobic exercise in DM and CKD rats submitted to the nephrotoxicity of the iodinated contrast .

Methods

Wistar rats were divided in groups: SHAM; CKD (nephrectomized animals, 5/6 renal mass); CKD+E (CKD submitted to swimming training, 60 min, 5 days, 4 weeks); aCKD (CKD received meglumine sodium ioxythalamate, contrast medium, 6 mL/kg, iv; once); aCKD+E (aCKD trained as described); Citrate (streptozotocin-STZ vehicle, 0.4 mL; ip; once); Citrate+E (Citrate trained as described); DM (STZ, 60 mg/kg, iv, once); DM+E (DM subjected to E as described); aDM+E (aDM trained as described). Renal function (inulin clearance, serum creatinine and microalbuminuria), hemodynamics (renal vascular flow and resistance) and oxidative profile (urinary peroxides, TBARS, nitric oxide and thiols) were evaluated.

Results

[Figure 1] [Figure 2].

Conclusion

Exercise was confirmed as a non-pharmacological therapy by reducing the progression of CKD and the diabetic kidney disease aggravated by the use of contrast, demonstrating improvement in renal function, renal hemodynamics and oxidative stress.

[Figure 1] CKD group: renal fuction, hemodynamics and oxidative stress

[Figure 1] DM group: renal fuction, hemodynamics and oxidative stress

Funding

  • Government Support – Non-U.S.