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Abstract: FR-PO931

Incident Events and Their Combinations After 6.5 Years of Follow-Up in the German Chronic Kidney Disease Study

Session Information

Category: CKD (Non-Dialysis)

  • 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Kotsis, Fruzsina Kinga, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany
  • Steinbrenner, Inga, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany
  • Lipovsek, Jan, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany
  • Stockmann, Helena, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
  • Schultheiss, Ulla T., Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany

Group or Team Name

  • GCKD Investigators
Background

Chronic kidney disease (CKD) patients are at an increased risk for adverse cardiovascular, non-cardiovascular events, and early mortality. Yet, a detailed analysis of the spectrum and patterns of adverse events from large CKD cohorts is lacking. We studied incident events, their combinations and mortality in the prospective German CKD (GCKD) study.

Methods

Incident events in the GCKD study are continuously adjudicated from hospital discharge records and death certificates following a standardized event catalogue containing: cardiovascular (“A”), cerebrovascular (“B”), peripheral arterial occlusive disease, (“C”), kidney (“E”), cancer (“G”), infection (“H”), and death (“F”) events. Event frequencies and their combinations were compared by sex. Incidence rates per 1000 patient-years (IR -/+recurrent events) were calculated. Combinations of events (intersection plot) were considered per participant regardless of time.

Results

Out of 5217 participants 60% were men. Over 6.5 years, 2933 participants (65.5% men) experienced at least one event. Incidence rates were overall (o) 97 (IR -); 338 (IR +). Men (m) experienced more events (108 IR -; 392 IR +) than women (w) (82 IR -; 260 IR +, respectively). Incidence rates were: A (o: 46; 114; m: 54; 135; w: 36; 82), E (o: 46; 75; m: 52; 85; w: 38; 61), H (o: 40; 66; m: 42; 68; w: 37; 63), F (o: 22; m: 28; w: 14; respectively). For 1314 participants, events in only one category (mainly A, E, H) were observed (Figure 1). In total, 787 participants experienced a combination of two events (66% men) and 467 a combination of 3 events (67% men). The most frequent combinations were (E, H; n=176) and (A, E, H; n=154).

Conclusion

This study provides a comprehensive overview of incident adverse events, their combinations, and differential events by sex in CKD patients under regular nephrological care. Cardiovascular, kidney and infection events were most frequent, and men experienced more events than women. Frequent events occurred in patients that also experienced an event of another category.

Funding

  • Government Support – Non-U.S.