ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2022 and some content may be unavailable. To unlock all content for 2022, please visit the archives.

Abstract: TH-PO825

Association Between Cardiorespiratory Fitness and Muscle Strength in Maintenance Hemodialysis Patients

Session Information

Category: Health Maintenance‚ Nutrition‚ and Metabolism

  • 1400 Health Maintenance‚ Nutrition‚ and Metabolism


  • Zhang, Kun, Tongji University, Shanghai, Shanghai, China
  • Zhu, Zhang-Yi, Tongji University, Shanghai, Shanghai, China
  • Li, Xin, Tongji University, Shanghai, Shanghai, China
  • Yu, Chen, Tongji University, Shanghai, Shanghai, China

Cardiovascular disease (CVD) is one of the most common complications in patients with maintenance hemodialysis (MHD). Cardiopulmonary fitness (CRF) was strongly associated with the incidence of CVD and the risk of all-cause death. MHD patients always have muscle wasting because of chronic inflammation, oxidative stress, dietary restrictions and other factors, but there is still a lack of relevant research between CRF and muscle strength in MHD patients. We aimed to investigate the association between cardiorespiratory fitness and muscle strength in maintenance hemodialysis (MHD) patients.


In this Cross-Sectional Study,patients who were ≥18 years old and were treated with regular MHD ≥3 months in MHD center from September 2020 to December 2020 were recruited. Cardiopulmonary exercise test (CPET) was used to test cardiorespiratory fitness (CRF) of MHD patients. Baseline data including body circumference, exercise capacity, upper and lower extremity muscle strength as well as clinical and biochemical data were collected. Correlation and hierarchical regression analysis was performed on the corresponding indicators to explore the influencing factors of CRF and the relationship between CRF and muscle strength.


A total of 48 patients were enrolled in our study, of whom 34 were male (70.8%) , the age was (60.31±10.44) years old, and the median dialysis vintage was 48(15,84) months. Furthermore, CRF was positively correlated with lower extremity muscle strength (r=0.322, P=0.026) and 6MWT (r=0.307, P=0.034) , was negatively correlated with age (r=-300, P=0.038). Multivariate linear regression analysis demonstrated that age (β=-0.235) and lower extremity muscle strength(β=0.241) were the influencing factor for peak VO2/kg.


Cardiorespiratory fitness were at an extremely low level, which is closely related to the lower extremity muscle strength in MHD patients.