ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: TH-PO880

Cognitive Patterns in Patients With CKD: The CKD-REIN Cohort Study

Session Information

Category: CKD (Non-Dialysis)

  • 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Levassort, Hélène, Clinique Ambroise Pare Service de Court Sejour Geriatrique, Boulogne-Billancourt, Île-de-France, France
  • Massy, Ziad, Hopital Ambroise-Pare Service de Nephrologie Dialyse, Boulogne-Billancourt, Île-de-France, France
  • Lambert, Oriane, Centre de Recherche en Epidemiologie et Sante des Populations, Villejuif, Île-de-France, France
  • Combe, Christian, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, Aquitaine, France
  • Fouque, Denis, Universite Claude Bernard Lyon 1, Villeurbanne, Auvergne-Rhône-Alpes , France
  • Laville, Maurice, Universite de Lyon, Lyon, Auvergne-Rhône-Alpes , France
  • Ayav, Carole, Centre hospitalier regional universitaire de Nancy, Nancy, Lorraine, France
  • Jacquelinet, Christian, Agence de la biomedecine, La Plaine Saint-Denis, France
  • Stengel, Benedicte, Centre de Recherche en Epidemiologie et Sante des Populations, Villejuif, Île-de-France, France
  • Pépin, Marion, Clinique Ambroise Pare Service de Court Sejour Geriatrique, Boulogne-Billancourt, Île-de-France, France

Group or Team Name

  • Center for research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Paris-Saclay University, Versailles Saint-Quentin-en-Yvelines University, National Institute of Health and Medical Research, Villejuif, France
Background

Chronic kidney disease (CKD) is associated with an increased risk of neurocognitive disorders (NCD). The global Mini Mental State Examination (MMSE) is often used to screen for cognitive impairment in patients with CKD, but the relative impact of CKD on the different cognitive domains of MMSE remains unexplored

Methods

We used the MMSE to assess orientation, memory, attention and calculation, langage and praxis, scores among 3033 patients (mean age, 66.82±12.87; 65.3% men) with all types of CKD and an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 included in the CKD-Renal Epidemiology and Information Network (CKD-REIN) cohort. Adjusted associations of patient characteristics with the global and domain-specific MMSE scores were estimated using linear regression models.

Results

The mean global MMSE score was 26.8/30 and the median score was 28/30. Two cognitive domains were significantly lower at lower eGFR level: orientation and praxis. After adjusting for age, sex, education, depressive symptoms, polymedication, psychoactive drug use, cerebrovascular disease, heart failure, history of depression and urinary albumin/creatinine ratio, low eGFR (expressed as 10 mL/min/1.73 m2), the orientation score was significantly lower, by 0.03 points [0.003, 0.05] for every 10 mL/min/1.73 m2 drop in eGFR (p=0.03), and praxis, by 0.01 points [0.002, 0.02] (p=0.01).

Conclusion

This study shows that orientation and praxis domains may be affected before the occurrence of clinically evident NCD, in patients with nondialysis CKD. This highlights the importance of screening individual cognitive domains in this population.

Funding

  • Other NIH Support