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Abstract: TH-PO924

ChAdOx1 nCoV-19 Immunogenicity and Immunological Response Following COVID-19 Infection in Patients Receiving Maintenance Hemodialysis

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Pongpirul, Krit, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Prasithsirikul, Wisit, Bamrasnaradura Infectious Disease Institute, Nonthaburi, Nonthaburi, Thailand
  • Nopsopon, Tanawin, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Phutrakool, Phanupong, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Kantagowit, Piyawat, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
  • Jongkaewwattana, Anan, National Center of Genetic Engineering and Biotechnology, Pathum Thani, Thailand
Background

This study aimed to evaluate the immunogenicity of two doses of ChAdOx1 nCoV-19 and the immune response post-COVID-19 infection in ESRD with HD patients.

Methods

The blood samples were obtained at baseline, 1-month, and 3-month follow-up after each shot or recovery. All participants were measured for anti-spike IgG by the ELISA method using Euroimmun.

Results

This study found a significant increase in anti-spike IgG after 1 month of two-shot ChAdOx1 nCoV-19 vaccination, followed by a significant decrease after 3 months. On the other hand, the anti-spike IgG was maintained in the post-recovery group. There was no significant difference in the change of anti-spike IgG between one-shot ChAdOx1 nCoV-19 vaccinated and post-recovery groups for both 1-month and 3-month follow-ups. The seroconversion rate for the vaccinated group was 60.32% at one-month after one-shot vaccination and slightly dropped to 58.73% at 3-month follow-up, then was 92.06% at one-month after two-shot vaccination and reduced to 82.26% at 3-month follow-up. For the recovered group, the seroconversion rate was 95.65% at one-month post-recovery and 92.50% at 3-month follow-up.

Conclusion

This study established the immunogenicity of two-shot ChAdOx1 nCoV-19 in ESRD patients with HD for humoral immunity. After COVID-19 infection, the humoral immune response was strong and could be maintained for at least three months.

Demographic Data of Participants
CharacteristicsTotalVaccinatedRecovered
Participants1096346
Age, year (mean ± SD)54.93 ± 15.2857.63 ± 14.8351.22 ± 15.26
Hypertension89 (81.65%)56 (88.89%)33 (71.74%)
Diabetes mellitus49 (44.95%)33 (52.38%)16 (34.78%)
Coronary artery disease4 (3.67%)3 (4.76%)1 (2.17%)

Data were presented as counts and percentages if not otherwise specified. SD: standard deviation.

Changes in anti-spike IgG in HD patients who received a single dose of ChAdOx1 and who recovered from COVID-19.

Funding

  • Government Support – Non-U.S.