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Abstract: FR-PO074

Association of Serum Ferritin and Hepcidin With Renal Recovery in Community Acquired AKI

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Sethi, Jasmine, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Kumar, Vivek, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
  • Yadav, Ashok Kumar, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
Background

Acute kidney injury (AKI) is an expanding overall health concern. The present study was designed to study the association of serum iron, ferritin and hepcidin with renal recovery at 4 months in patients of community acquired AKI.

Methods

It is a prospective observational cohort study. All admitted patients aged between 13-70 years and diagnosed to have CA-AKI were eligible for screening. Patients with pre-existing CKD, suspected glomerulonephritis, chronic liver disease, transplant recipients, previous history of blood transfusion and suspected malignancy were excluded. The subjects had scheduled follow up visits at 1 and 4 months after discharge with renal function test and spot urinary PC ratio.

Results

Between October 2020 to July 2021, 100 patients of community acquired acute kidney injury were enrolled in the study after taking informed consent.Out of 100, 4 patients expired and 1 patient was lost to follow up. Out of 95 patients, 76 patients had complete renal recovery whereas 19 patients progressed to chronic kidney disease at the end of 3 months. The mean age of the study sample was 43.2 years with sex ratio of 2:1. Most common aetiology of CAAKI was found to be sepsis related which accounted for 42% cases followed by tropical illness and pancreatitis contributing almost equally 17% and 16% respectively. Other rare causes include snake/ wasp bite (5%), poisoning (3%), acute gastroenteritis(10%). Around half of the cohort had stage 3 acute kidney injury at admission. Higher baseline serum Ferritin and hepcidin showed a statistically significant association with renal recovery at 4 months. On multivariate analysis Diabetes, Ferritin and Hepcidin were significantly affecting renal recovery at 4 months.

Conclusion

Renal non recovery was seen in a significant proportion of patients (n=19, 20%) with community-acquired AKI. Elevated baseline serum ferritin and hepcidin were associated with a favourable renal outcome in CA-AKI. Ferritin and hepcidin can be used as prognostic markers in patients with AKI for predicting renal recovery.