Kidney Week

Abstract: TH-PO473

Incidence of Thromboembolic Events Among Glomerular Disease Participants in the Cure Glomerulonephropathy Network (CureGN)

Session Information

• Glomerular Diseases: Clinical, Outcomes, Trials - I
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1303 Glomerular Diseases: Clinical‚ Outcomes‚ and Trials

Authors

• Khalid, Myda, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, United States

Myda Khalid,

• Mansfield, Sarah, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Sarah Mansfield,

• Smith, Abigail R., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Abigail R. Smith,

• Robinson, Bruce M., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States

Bruce M. Robinson,

• Abdelghani, Eman, Nationwide Children's Hospital, Columbus, Ohio, United States

Eman Abdelghani,

• Al-Uzri, Amira, Oregon Health & Science University, Portland, Oregon, United States

Amira Al-Uzri,

• Bartosh, Sharon M., University of Wisconsin-Madison, Madison, Wisconsin, United States

Sharon M. Bartosh,

• Gipson, Debbie, University of Michigan, Ann Arbor, Michigan, United States

Debbie Gipson,

• Kerlin, Bryce A., Nationwide Children's Hospital, Columbus, Ohio, United States

Bryce A. Kerlin,

• Rheault, Michelle N., University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States

Michelle N. Rheault,

• Sperati, John, Johns Hopkins Medicine, Baltimore, Maryland, United States

John Sperati,

• Srivastava, Tarak, Children's Mercy Hospitals and Clinics, Kansas City, Missouri, United States

Tarak Srivastava,

• Wong, Craig S., University of New Mexico School of Medicine, Albuquerque, New Mexico, United States

Craig S. Wong,

• Wadhwani, Shikha, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

Shikha Wadhwani,

Group or Team Name

• CureGN ERO Writing Group

Background

Thromboembolic (TE) events are well-known complications of glomerular disease, but incidence rates and risk factors are not well-defined. This analysis describes TE outcomes in CureGN, a prospective cohort study of adults and children with biopsy-proven minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy/vasculitis (IgA) from 65 US and 6 international sites.

Methods

Multivariable Cox regression was used to estimate associations with first post-enrollment TE event, among those without a prior event.

Results

Among 2423 participants (566 MCD, 615 FSGS, 546 MN, 696 IgA), enrollment characteristics were: median age 31 yr (IQR 14-51), 35% children, 57% male, 13% Hispanic, 16% Black, median eGFR 83ml/min/1.73m² (IQR 54-103), median UPCR 1.2 g/g (IQR 0.2-3.9). Median follow-up was 3.8 years (IQR 2.2-5.1). Overall, 46 participants (12 children, 34 adults) experienced at least one TE event, most commonly deep vein thrombosis, followed by pulmonary embolism. The cumulative incidence at 1-, 3-, and 5-years post-enrollment was 0.6%, 1.5%, and 1.8%, respectively, for children, and 1.9%, 3.3%, and 4.4%, respectively, for adults. First TE events were associated with Black race (HR=2.3, 95% CI=1.2-4.5) and lower serum albumin ((HR=0.67 per g/dL, 95% CI=0.47-0.94), as well as with older age, tobacco use, higher body mass index, and lower eGFR [Figure]. Glomerular disease subtype was not associated with TE events (p=0.74).

Conclusion

TE events frequently complicate glomerular disease and in this cohort were associated with with particular demographic and clinical characteristics. Additional data will extend understanding of thromboembolic risk in patients with glomerular disease and inform practice guidelines.

Cox regression models for time to thromboembolic event

Funding

• NIDDK Support