ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2022 and some content may be unavailable. To unlock all content for 2022, please visit the archives.

Abstract: FR-PO498

Phloretin Improves Ultrafiltration and Reduces Glucose Absorption During Peritoneal Dialysis in Rats

Session Information

Category: Dialysis

  • 702 Dialysis: Home Dialysis and Peritoneal Dialysis


  • Bergling, Karin, Lunds Universitet, Lund, Sweden
  • Martus, Giedre, Lunds Universitet, Lund, Sweden
  • Öberg, Carl Mikael, Lunds Universitet, Lund, Sweden

Harmful glucose exposure and absorption remain major limitations of peritoneal dialysis. We previously showed that inhibition of sodium glucose co-transporter 2 did not affect glucose transport during peritoneal dialysis in rats. However, more recently we found that phlorizin, a dual blocker of sodium glucose co-transporter 1 and 2, was effective in reducing glucose diffusion in peritoneal dialysis, implicating either that sodium glucose co-transporter 1 inhibition or blockade of facilitative glucose channels by phlorizin metabolite phloretin would be effective in reducing glucose transport in peritoneal dialysis.


Here we tested a selective blocker of sodium glucose co-transporter 1, mizagliflozin, as well as phloretin, a non-selective blocker of facilitative glucose channels in an experimental model of peritoneal dialysis in anesthetized Sprague-Dawley rats.


Intra-peritoneal phloretin treatment reduced glucose absorption by more than 30% and resulted in a more than 50% higher ultrafiltration rate compared to control animals. Sodium removal and sodium clearances were similarly improved, whereas there was no difference in the amount of ultrafiltration per mmol sodium removed. Mizagliflozin did not influence glucose transport or osmotic water transport.


Taken together, our present and previous results indicate that blockers of facilitative glucose channels may be a promising target for reducing glucose absorption and improving ultrafiltration efficiency.

Forest plot of phloretin effect sizes. 95% confidence intervals of phloretin effect on Isocratic, Isovolumetric and Three-pore model glucose diffusion capacity (MTAC), Three-pore model urea MTAC, ultrafiltration-rate (UF-rate) and sodium removal compared to sham group. Interval marker represent the median of the difference.


  • Government Support – Non-U.S.