Abstract: FR-PO670
Can PLA2R Antigen in Kidney Tissue Turn Positive After Recent COVID-19 Infection in Membranous Nephropathy?
Session Information
- Glomerular Diseases: Clinical, Outcomes, Trials - II
November 04, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1303 Glomerular Diseases: Clinical‚ Outcomes‚ and Trials
Authors
- Bukhari, Syeda Sadia, Kings County Hospital Center, Brooklyn, New York, United States
- Elhawary, Omar Nabil, Kings County Hospital Center, Brooklyn, New York, United States
- Puri, Isha, Kings County Hospital Center, Brooklyn, New York, United States
- Mallappallil, Mary C., Kings County Hospital Center, Brooklyn, New York, United States
- Agarwal, Sonalika, Kings County Hospital Center, Brooklyn, New York, United States
Introduction
COVID-19 infection has been associated with variety of kidney diseases including glomerulopathies. To our knowledge, only 8 cases of membranous nephropathy post COVID infection have been reported so far out of which 3 were PLA2R antigen positive. We report another case of such a rare association.
Case Description
33 y/o AA obese male admitted with worsening anasarca for 1 month. His labs showed normal kidney function, hypoalbuminemia and nephrotic range proteinuria of 4 g/d. Urinalysis was otherwise bland. Serology including ANA, ANCA, C3, C4, Anti-PLA2R, Hepatitis panel, HIV were all negative. USG showed normal kidneys. Kidney biopsy was done which showed membranous nephropathy. There were no signs of virus in the kidney tissue. He stained positive for PLA2R antigen. Further history revealed that he had mild COVID infection 2 weeks before the swelling started. He did not require hospital admission. For his kidney disease, he is started on losartan and diuretics. He is being observed for 6 months for possible spontaneous resolution.
Discussion
Based on the clinical presentation and serology it would suggest that the patients with COVID-19 infection may be associated with subsequent membranous nephropathy. The clinical presentation of the infection two weeks prior may be the stimuli for the PLAR2 antigen and the membranous nephropathy, while the serum anti-PLA2R antibody was negative.