ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: TH-PO893

Impact of Caring for Individuals With CKD in the United States: A Systematic Literature Review

Session Information

Category: CKD (Non-Dialysis)

  • 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention


  • Osenenko, Katherine M., Broadstreet HEOR, Vancouver, British Columbia, Canada
  • Chatterjee, Satabdi, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, United States
  • Ray, Saurabh, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, United States
  • Li, Tina, Broadstreet HEOR, Vancouver, British Columbia, Canada
  • Donato, Bonnie M.k., Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, United States

Individuals with chronic kidney disease (CKD) often rely upon the support of unpaid caregivers (CGs) who play a critical role in assisting with disease management activities. While the importance of CGs’ roles is widely recognized, the impact to CGs is not well characterized, including time required for care duties and negative impacts to CG health and well-being. The objective of this review was to synthesize contemporary estimates of economic, clinical, and humanistic impact among CGs of patients with CKD in the United States (US).


A systematic review was conducted using MEDLINE and Embase to identify studies reporting estimates of CG impact in the US, published between 2016-2021. Study selection and data extraction were performed in duplicate, in accordance with PRISMA guidelines. A grey literature search was conducted for the past 5 years. Characteristics of patients with CKD and their CGs were summarized, as well as estimates of the economic, clinical, and humanistic impact to CGs.


From 2,990 abstracts, 8 studies reporting CG burden estimates were included. Mean CG age ranged from 61-63 years; CGs were primarily female (57.9-78.4%) and the patient’s spouse/partner (42.1-45.3%). Time spent caregiving ranged from 27-38 hours/week (2 studies) and caregiving duration from 3.7-5.0 years (2 studies). In one study, 69.1% of CGs for those with CKD and anemia made at least one job-related decision due to caregiving, including retiring early, reducing work hours, or quitting their job. Depression was identified in 31.6-36.4% CGs (2 studies), while 31.6- 43.6% had anxiety (2 studies). Although a variety of instruments were used to measure humanistic burden, studies consistently documented the high impact of caregiving for patients with CKD.


This review demonstrates the considerable burden of caring for individuals with CKD; however, estimates of CG impact were sparse and heterogenous. Despite limited data, notable findings include the large amount of time spent caregiving and frequent identification of depression and anxiety among CGs. Future research is needed to better characterize the impact to those caring for individuals with CKD, including economic burden and healthcare resource use, as well as the evaluation of drivers of burden.