Kidney Week

Abstract: TH-PO680

Iron Deficiency Impairs Skeletal Muscle Mitochondrial Function and Exercise Performance in CKD

Session Information

• Anemia and Iron Metabolism
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Anemia and Iron Metabolism

• 200 Anemia and Iron Metabolism

Authors

• Oliveira, Benjamin A., King's College London, London, London, United Kingdom

Benjamin A. Oliveira,

• Mangahis, Emmanuel, King's College Hospital NHS Foundation Trust, London, London, United Kingdom

Emmanuel Mangahis,

• Reid, Fiona, King's College London, London, London, United Kingdom

Fiona Reid,

• Burton, James, University of Leicester, Leicester, Leicestershire, United Kingdom

James Burton,

• Mccafferty, Kieran, The Royal London Hospital, London, London, United Kingdom

Kieran Mccafferty,

• Wilkinson, Thomas James, University of Leicester, Leicester, Leicestershire, United Kingdom

Thomas James Wilkinson,

• Asgari, Elham, Guy's and St Thomas' NHS Foundation Trust, London, London, United Kingdom

Elham Asgari,

• Beckley-Hoelscher, Nick, King's College London, London, London, United Kingdom

Nick Beckley-Hoelscher,

• Banerjee, Debasish, St George's University Hospitals NHS Foundation Trust, London, London, United Kingdom

Debasish Banerjee,

• Watson, Emma L., University of Leicester, Leicester, Leicestershire, United Kingdom

Emma L. Watson,

• Swift, Pauline A., Epsom and Saint Helier University Hospitals NHS Trust, Carshalton, Sutton, United Kingdom

Pauline A. Swift,

• Lightfoot, Courtney Jane, University of Leicester, Leicester, Leicestershire, United Kingdom

Courtney Jane Lightfoot,

• Baker, Luke A., University of Leicester, Leicester, Leicestershire, United Kingdom

Luke A. Baker,

• Reid, Chante, King's College Hospital NHS Foundation Trust, London, London, United Kingdom

Chante Reid,

• Wheeler, David C., University College London, London, London, United Kingdom

David C. Wheeler,

• Smith, Alice C., University of Leicester, Leicester, Leicestershire, United Kingdom

Alice C. Smith,

• Greenwood, Sharlene A., King's College Hospital NHS Foundation Trust, London, London, United Kingdom

Sharlene A. Greenwood,

• Bramham, Kate, King's College London, London, London, United Kingdom

Kate Bramham,

• Ayis, Salma, King's College London, London, London, United Kingdom

Salma Ayis,

• Kalra, Philip A., Salford Royal NHS Foundation Trust, Salford, Salford, United Kingdom

Philip A. Kalra,

• Bhandari, Sunil, Hull University Teaching Hospitals NHS Trust, Hull, Kingston upon Hull, United Kingdom

Sunil Bhandari,

• Macdougall, Iain C., King's College Hospital NHS Foundation Trust, London, London, United Kingdom

Iain C. Macdougall,

• Okonko, Darlington, King's College London, London, London, United Kingdom

Darlington Okonko,

Background

Skeletal muscle (SM) mitochondrial oxidative phosphorylation (OXPHOS) is impaired in patients with CKD and could be worsened by iron deficiency (ID).

Methods

We quantified SM OXPHOS and exercise capacity in CKD pts with a Hb > 110 g/dL (n=38, Table 1), and in healthy volunteers (n=6). SM OXPHOS was measured using high resolution respirometry (HRR) of quadriceps biopsies and using 31-phosphorus magnetic resonance spectroscopy (31P-MRS).

Results

On HRR, carbohydrate (Fig A) but not fatty-acid (Fig B) driven maximal coupled OXPHOS capacity was lowest in pts with ID, but was a higher % of maximal uncoupled ETC capacity in these pts (Fig C) implying that mitochondria were operating at their maxima. Pts with ID also had longer phosphocreatinine recovery halftime on 31P-MRS (33 vs. 25 vs. 17 s, P<0.01) and lower exercise capacity (Fig D, E). Adjustment for Hb did not alter results.

Conclusion

ID intrinsically correlates with worse SM OXPHOS in CKD.

Funding

• Private Foundation Support