Abstract: SA-PO758
High Tissue Sodium Associates With Insulin Resistance in Prehypertensive Obese Individuals
Session Information
- Hypertension and CVD: Mechanisms
November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1503 Hypertension and CVD: Mechanisms
Authors
- Ertuglu, Lale A., Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Sahinoz, Melis, Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Akwo, Elvis Abang, Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Guide, Andrew, Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Stewart, Thomas G., Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Pike, Mindy, Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Robinson-Cohen, Cassianne, Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Madhur, Meena S., Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Harrison, David G., Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Ikizler, Talat Alp, Vanderbilt University Medical Center, Nashville, Tennessee, United States
Background
High tissue sodium (Na+) accumulation plays a role in the development of hypertension by activation of inflammatory and metabolic pathways. We sought to determine if tissue Na+ content is associated with insulin sensitivity (IS) in patients with early hypertension, a known metabolic derangement commonly observed in patients with kidney and cardiovascular disease.
Methods
Tissue Na+ accumulation and IS were assessed in 83 participants with early hypertension (SBP 120 - 139 mmHg or DBP 70 - 89 mmHg) using 23NaMRI and hyperinsulinemic euglycemic clamp technique. Glucose disposal rate (GDR) was used as the marker of IS. High-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) were used as markers of inflammation.
Results
GDR did not significantly associate with tissue Na+ in the entire cohort. In subgroup analysis according to obese vs lean, GDR significantly associated with muscle and skin Na+ among the obese (β=-1.11, 95% CI = -1.99, -0.24 and β=-0.45, 95% CI = -0.83, -0.07 for muscle and skin Na+, respectively) but not in lean participants. Among obese participants, there was significant effect modification by the inflammatory markers. The changes in GDR per unit changes in tissue Na+ were greater at higher levels of hsCRP (p=0.03 and 0.01 for muscle and skin Na+, respectively) and IL-6 (p=0.05 and 0.01 for muscle and skin Na+, respectively). This was not observed in lean participants.
Conclusion
Our data show a significant negative association between muscle and skin Na+ and IS in the obese, but not in lean individuals with early hypertension. Systemic inflammation may play a key role in the relationship between tissue Na+ and IS.
Funding
- NIDDK Support