Kidney Week

Abstract: TH-PO846

Coffee Consumption and Risk of Kidney Function Decline in a Dutch Population-Based Cohort

Session Information

• Health Maintenance, Nutrition, Metabolism
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance‚ Nutrition‚ and Metabolism

• 1400 Health Maintenance‚ Nutrition‚ and Metabolism

Authors

• Cai, Qingqing, Universiteit Groningen Faculteit Medische Wetenschappen, Groningen, Groningen, Netherlands

Qingqing Cai,

• Westing, Anniek Van, Wageningen University, Wageningen, Gelderland, Netherlands

Anniek Van Westing,

• Bakker, Stephan J.L., Universiteit Groningen Faculteit Medische Wetenschappen, Groningen, Groningen, Netherlands

Stephan J.L. Bakker,

• Navis, Gerjan, Universiteit Groningen Faculteit Medische Wetenschappen, Groningen, Groningen, Netherlands

Gerjan Navis,

• Geleijnse, Johanna M., Wageningen University, Wageningen, Gelderland, Netherlands

Johanna M. Geleijnse,

• De Borst, Martin H., Universiteit Groningen Faculteit Medische Wetenschappen, Groningen, Groningen, Netherlands

Martin H. De Borst,

Background

Coffee consumption has been associated with beneficial outcomes in various disease domains, including chronic kidney disease (CKD). Whether coffee consumption is associated with kidney function decline in the general population is unclear. We investigated the association of coffee consumption with kidney function decline or incident chronic kidney disease (CKD) in the Dutch population.

Methods

This study was performed in 78,346 participants free of CKD in the prospective population-based Lifelines cohort from Northern Netherlands. Coffee consumption (daily cups) was assessed at baseline using food frequency questionnaires. Incident CKD was defined as eGFR <60 mL/min/1.73 m² (CKD-EPI equation). Multivariable logistic regression analyses were used to evaluate the associations of daily coffee consumption with annual change in estimated glomerular filtration rate (eGFR) or a composite kidney outcome (incident CKD and/or >20% eGFR decline).

Results

Participants with higher daily coffee intakes were more often men, older, lower-educated, and current smoker. They were less physically active and had higher BMI, higher alcohol intake, and lower tea intake. They also had less often diabetes and cardiovascular disease and more often gastrointestinal disease. During a mean (SD) follow-up of 3.6±0.9 years, 8 735 events (11.1%) of the composite kidney outcome occurred. The median (IQR) annual change in eGFR was -2.23 (-3.69, -0.80) mL/min/1.73 m². Coffee intake was inversely associated with annual eGFR decline (ß [95%CI] for 1-2 cups, 0.13 [0.06-0.21]; 3-4 cups, 0.15 [0.08, 0.23]; 5-6 cups, 0.19 [0.11, 0.27]; and >6 cups, 0.23 [0.14, 0.33], vs non-coffee drinkers, P_trend <0.001). Similar dose-response relationships were observed for composite kidney outcome. Coffee intake (continuously, per cup/d) was related to a lower risk of the composite kidney outcome (OR [95%CI], 0.98 [0.97,0.99], P=0.02).

Conclusion

Daily coffee consumption was inversely associated with kidney function decline and CKD risk in a dose-response manner in Dutch population-based cohort. Intervention studies are needed to address whether increasing coffee consumption protects against kidney function loss.

Funding

• Government Support – Non-U.S.