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Abstract: FR-PO072

Serum Response Factor, a Novel Early Diagnostic Biomarker of AKI

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology‚ Risk Factors‚ and Prevention

Authors

  • Zhao, Long, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
  • Xu, Yan, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
Background

Studies have shown that serum response factor (SRF) is increased in chronic kidney injury, such as diabetic nephropathy, hyperuricemic nephropathy and renal cell carcinoma. The objective is to explore the early diagnostic value of SRF in acute kidney injury (AKI).

Methods

AKI-related microarray data were analyzed, and the expression and location of SRF were investigated in the early phase of AKI.

Results

Bioinformatics results demonstrated that SRF was dramatically elevated 2-4 h after ischemia/reperfusion (I/R) in mouse renal tissue (Figure 1). In I/R rats, SRF was mostly expressed and located in renal tubular epithelial cells (TECs) (Figure 2). SRF started to increase at 1 h, peaked at 3-9 h and started to decrease at 12 h after I/R (Figure 3-4). The areas under the ROC curve of renal SRF mRNA, renal SRF protein, urinary SRF, serum SRF and serum creatinine (Scr) were 87.9%, 83.0%, 81.3%, 78.8%, 68.8%, respectively (Figure 5).

Conclusion

SRF is remarkably upregulated in early (before 24 h) AKI and can replace Scr as a potential new early diagnostic biomarker of AKI.

Funding

  • Government Support – Non-U.S.