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Abstract: SA-PO949

Preliminary Self-Report Findings From the NIH Emotional Toolbox Among Youth With CKD

Session Information

Category: CKD (Non-Dialysis)

  • 2202 CKD (Non-Dialysis): Clinical‚ Outcomes‚ and Trials


  • Johnson, Rebecca J., Children's Mercy Kansas City, Kansas City, Missouri, United States
  • Harshman, Lyndsay, The University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, United States
  • Lande, Marc, University of Rochester Medical Center, Rochester, New York, United States
  • Carlson, Joann M., Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States
  • Wilson, Camille, Nationwide Children's Hospital, Columbus, Ohio, United States
  • Dawson, Anne E., Nationwide Children's Hospital, Columbus, Ohio, United States
  • Matheson, Matthew, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
  • Furth, Susan L., The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
  • Warady, Bradley A., Children's Mercy Kansas City, Kansas City, Missouri, United States
  • Hooper, Stephen R., University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States

On measures of psychopathology, children with chronic kidney disease (CKD) are known to be at risk for inattention and internalizing symptoms such as sadness and anxiety. Less is known about their self-report of overall emotional health. The NIH Emotional Toolbox assesses negative emotions as well as psychological well-being, social relationships, stress, and self-efficacy.


The Chronic Kidney Disease in Children (CKiD) study is a multi-site, prospective cohort of children with eGFR 30-90ml/min/1.73m2 at entry. In the past 3 years, 57 participants aged 8-17 have completed the NIH Emotional Toolbox. Linear regression models examined associations between emotional constructs and disease-related variables known to be associated with emotional health (glomerular diagnosis, urine Pr/Cr, blood pressure). These variables were hypothesized to be associated with poorer emotional and social health. Models were adjusted for U25eGFR, age, sex, and maternal education. Significance was set as p <= .01.


16 participants aged 8-12 and 41 aged 13-17 completed assessment of 11 NIH Emotional Toolbox constructs in 4 domains (Psychological Well-Being, Social Relationships, Stress and Self-Efficacy, and Negative Emotions). Median age was 14.7 [IQR=12.8,16.4], 58% were male, 16% had glomerular diagnosis, 78% of mothers had completed education beyond high school, median urine Pr/Cr was 0.23 [IQR=0.12,0.76], 75% were normotensive, and median eGFR was 52 [IQR 40, 70]. Emotional Toolbox T scores placed in the average range across constructs (median scores 43-55). Glomerular diagnosis was significantly associated with the construct positive affect in that participants with glomerular disease reported less positive affect (β=-13.54, 99% CI=-23.58, -3.50; p=.0007); this finding reflected a large effect size.


Preliminary findings suggest average self-reported emotional health for a subset of children enrolled in the CKiD study who completed the NIH Emotional Toolbox. Glomerular diagnosis was associated with less positive affect. A larger, more diverse sample of children with CKD is needed to determine if other disease-related variables are associated with emotional health. Future analyses will examine parent proxy report of emotional health for this cohort.


  • NIDDK Support